Pax 6: mastering eye morphogenesis and eye evolution
Abstract
Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution.
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What is actually homologous in the role of pax6 in diversely constructed eyes is only its function in controlling genes encoding visual pigments; the gene was later coopted for different morphogenetic programs.
“The alternative is that what is actually homologous in the role of the pax6 gene in the diversely constructed eyes of various bilaterians is only its function in the control of genes encoding visual pigments.”
From The last common bilaterian ancestor (2002) · cites this paper as Gehring and Ikeo, 1999
The idea of 'intercalary evolution' has been adduced to explain the utilization of given regulatory genes in both terminal differentiation gene batteries and upstream developmental GRNs.
“The idea of ' intercalary evolution ' has been adduced to explain the utilization of given regulatory genes in both terminal differentiation gene batteries and upstream developmental GRNs (8, 41).”
From Transphyletic conservation of developmental regulatory state in animal evolution (2011) · cites this paper as [41]
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References 44 · Cited by 758
- Authors
- Gehring, W. J., & Ikeo, K.
- Affiliations
- University of Basel (CH)
- National Institute of Genetics (JP)
- Corresponding author
- Gehring, Walter J
- Ikeo, Kazuho
- ORCID
- Ikeo, Kazuho
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 15
- Issue
- 9
- Pages
- 371-377
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2126414770
- Cited by
- 758
- References
- 44
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 14 · 2022: 10 · 2021: 24 · 2020: 20 · 2019: 9 · 2018: 13 · 2017: 24 · 2016: 28 · 2015: 36 · 2014: 21 · 2013: 28 · 2012: 29
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Ocular Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Pax6, eye morphogenesis, eye evolution
- MeSH terms
- PAX6 Transcription Factor, Amino Acid Sequence, Animals, DNA-Binding Proteins, Biological Evolution, Eye, Eye Proteins, Humans, Molecular Sequence Data, Repressor Proteins, Sequence Homology, Amino Acid, Homeodomain Proteins, Paired Box Transcription Factors
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