Oral glucocorticoids and their complications
Abstract
Glucocorticoid preparations form one of the cornerstones of the modern medical pharmacopeia. This class of medications has been especially useful to dermatologists, who are purported to be among its most prolific users. Oral glucocorticoids, available now for over 30 years, are prescribed to over 7% of hospitalized patients. Of this group, some 17% may experience adverse effects. It behooves any physician who uses these powerful agents to be aware of the potential complications and side effects. In this article we have undertaken to summarize and discuss selective examples of this rapidly growing segment of the literature.
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Prolonged exposure to GCs can result in side effects including central adiposity, insulin resistance and gastrointestinal complications.
“However, prolonged exposure to GCs can result in various side effects, including central adiposity, insulin resistance and gastrointestinal complications.19,20”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [19]
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References 175 · Cited by 115
- Authors
- Gallant, C., & Kenny, P.
- Affiliations
- Western University (CA)
- Corresponding author
- Gallant, C.
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 1986-02
- Volume
- 14
- Issue
- 2
- Pages
- 161-177
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2037276525
- Cited by
- 115
- References
- 175
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- oral corticosteroids, adverse drug reactions, corticosteroid adverse effects, hospitalized patients
- MeSH terms
- Administration, Oral, Animals, Cardiovascular Diseases, Connective Tissue, Eye Diseases, Female, Gastrointestinal Diseases, Glucocorticoids, Half-Life, Humans, Hypothalamo-Hypophyseal System, Immunity, Infections, Mineralocorticoids, Neoplasms, Osteoporosis, Pancreatitis, Pituitary-Adrenal System, Pregnancy, Pregnancy Complications, Stomach Diseases, Tuberculosis, Substance-Related Disorders
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