Pharmacology and chemistry of adapalene

The retinoid signaling pathway: molecular and genetic analyses

Chambon, P. (1994) · Seminars in Cell Biology · doi:10.1006/scel.1994.1015 · Cited by 502

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

Bernard, B. A., Bernardon, J., Delescluse, C., Martin, B., Lenoir, M.-C., Maignan, J., Charpentier, B., Pilgrim, W. R., Reichert, U., & Shroot, B. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90842-9 · Cited by 201

Synthesis, Structure-Affinity Relationships, and Biological Activities of Ligands Binding to Retinoic Acid Receptor Subtypes

Charpentier, B., Bernardon, J., Eustache, J., Millois, C., Martin, B., Michel, S., & Shroot, B. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00026a006 · Cited by 122

Prostaglandin and Leukotriene Synthesis in Mouse Ears Inflamed by Arachidonic Acid

Opas, E. E., Bonney, R. J., & Humes, J. L. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12265320 · Cited by 120

Differential Regulation of Retinoic Acid Receptors and Binding Proteins in Human Skin

Elder, J. T., Åström, A., Pettersson, U., Tavakkol, A., Griffiths, C. E. M., Krust, A., Kastner, P., Chambon, P., & Voorhees, J. J. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12499896 · Cited by 116

Retinoic acid-induced modifications in the growth and cell surface components of a human carcinoma (HeLa) cell line

Lotan, R., Krämer, R., Neumann, G., Lotan, D., & Nicolson, G. L. (1980) · Experimental Cell Research · doi:10.1016/0014-4827(80)90018-x · Cited by 63

Biological Activity of Retinoids Correlates with Affinity for Nuclear Receptors but Not for Cytosolic Binding Protein

Darmon, M. Y., Rocher, M. N., Cavey, M. T., Martin, B., Rabilloud, T., Delescluse, C., & Shroot, B. (2009) · Skin Pharmacology · doi:10.1159/000210770 · Cited by 57

Comparison of CD271 (Adapalene) and All-Trans Retinoic Acid in Human Skin: Dissociation of Epidermal Effects and CRABP-II mRNA Expression

Griffiths, C. E. M., Elder, J. T., Bernard, B. A., Rossio, P., Cromie, M. A., Finkel, L. J., Shroot, B., & Voorhees, J. J. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12365480 · Cited by 49

Quantification of Epidermal Histological Changes Induced by Topical Retinoids and CD271 in the Rhino Mouse Model Using a Standardized Image Analysis Technique

Bouclier, M., Chatelus, A., Ferracin, J., Delain, C., Shroot, B., & Hensby, C. N. (2009) · Skin Pharmacology · doi:10.1159/000210926 · Cited by 45

Control of Epidermal Differentiation by a Retinoid Analogue Unable to Bind to Cytosolic Retinoic Acid-Binding Proteins (CRABP)

Asselineau, D., Cavey, M. T., Shroot, B., & Darmon, M. Y. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12555633 · Cited by 36

Retinoid Therapy of Acne and Sebocyte-Related Disorders

Taylor, G. A., & Shalita, A. R. (2007) · Basic and clinical dermatology · doi:10.3109/9781420021189.006 · Cited by 4

Photosensitizing Properties of the Topical Retinoid Drug Adapalene

Soler-Orenes, J. A., Rodríguez‐Muñiz, G. M., Hernández‐Gil, J., Miranda, M. A., Andreu, I., & Lhiaubet‐Vallet, V. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.4c00384 · Cited by 3

COMPARISION OF CLINICAL EFFICACY OF TOPICAL CLINDAMYCIN WITH ADAPALENE AND ADAPALENE ALONE IN TREATMENT OF MILD TO MODERATE FACIAL ACNE VULGARIS

K.Nandimath., N. B. R. A. M. (2013) · International Journal of Pharma and Bio Sciences · Cited by 3

A RATIONAL PHARMACOTHERAPEUTIC STUDY IN PHARMACOVIGILANCE: A COMPARATIVE ASSESSMENT OF SAFETY BETWEEN TOPICAL 1% NADIFLOXACIN AND 0.1% ADAPALENE COMBINATION THERAPY AND TOPICAL 1% NADIFLOXACIN AND 0.025% TRETINOIN COMBINATION THERAPY, IN MILD TO MODERATE ACNE, IN TERTIARY CARE HOSPITALS, IN INDIA

Hazra, M. (2019) · Journal of Evidence Based Medicine and Healthcare · doi:10.18410/jebmh/2019/484 · Cited by 3

Estudo clínico aberto multicêntrico da efetividade e tolerabilidade do gel de adapaleno a 0,1%* em pacientes com acne vulgar

Ramos‐e‐Silva, M., Carneiro, S. C. D. S., Ponzio, H. A. S., Assunção, B. F. G., Cardoso, A. E. C., de Almeida, F. A., Zaitz, C., & Campbell, I. T. (2003) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962003000200003 · Cited by 3

A Review on a Third Generation Retinoidal Agent: Adapalene

Ali, S., Rawat, N., & Husain, A. (2016) · Cited by 3

Impaired retinoic acid signaling mediated Rbm20 downregulation induces aberrant splicing of CaV1.2 calcium channel: implications in myocardial hypertrophy

Song, X., Yang, D., Sun, Z., Yin, S., Wang, C., Hou, W., Sun, Y., Zheng, F., & Wang, J. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.11.011 · Cited by 2

Thin layer chromatographic compatibility study in preformulation of new transdermal therapeutic systems

Moldovan, O.-L., Brihan, D.-N., Todoran, N., & Rusu, A. (2020) · Acta Marisiensis. Seria Medica · doi:10.2478/amma-2020-0004 · Cited by 2

Fabrication and functional attributes of nanotherapeutically engineered system for co-administration of adapalene and lycopene for enhanced acne management: an in vitro and in vivo investigation

Jain, A., & Mehta, P. D. (2023) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-023-00403-7 · Cited by 2

Comparison of adapalene solution, 0.1% and tretinoin gel, 0.025% in the topical treatment of acne vulgaris

Ellis, C. N. (1998) · Journal of the European Academy of Dermatology and Venereology · doi:10.1016/s0926-9959(98)95257-6 · Cited by 2

TERAPIA RETINÓIDE NA ACNE VULGAR

Vinhal, D. C., Roberth, A. O., Ortence, V. O. P., & Diniz, D. G. A. (2014) · Revista Eletrônica de Farmácia · doi:10.5216/ref.v11i3.27721 · Cited by 2

Formulation, in vitro release and transdermal diffusion of selected retinoids

Krüger, A. (2010) · Cited by 2

Retinoids in Clinical Use

Njar, V. C. O. (2008) · Methods and principles in medicinal chemistry · doi:10.1002/9783527623297.ch12 · Cited by 2

Topical Retinoids and Acne

Marchitto, M. C., Kang, S., & Chien, A. L.-L. (2021) · Updates in clinical dermatology · doi:10.1007/978-3-030-68996-4_5 · Cited by 2

Retinoids enhance NK effector function against HIV-infected CD4 T cells

McMahon, E. K., Lochner, J. S., Lynch, R. M., & Bosque, A. (2026) · Journal of Virology · doi:10.1128/jvi.01620-25 · Cited by 1

Adapalene, an RAR agonist, exerts anti-inflammatory effects by regulating macrophage polarization through RAR$$\upbeta$$-mediated signaling pathways

Lee, N. H., Choi, M. J., Ji, S. M., Kwak, H. J., & Cheon, H. G. (2026) · Scientific Reports · doi:10.1038/s41598-026-44454-z · Cited by 1

Topical Retinoids

Thielitz, A., & Gollnick, H. P. M. (2014) · Springer eBooks · doi:10.1007/978-3-540-69375-8_57 · Cited by 1

A rational pharmacotherapeutic study of comparative safety among topical anti-acne 1% nadifloxacin monotherapy, 0.1% adapalene monotherapy, 0.025% tretinoin monotherapy, 1% nadifloxacin and 0.1% adapalene combination therapy and 1% nadifloxacin and 0.025% tretinoin combination therapy, in mild to moderate acne vulgaris, in tertiary care hospitals

Hazra, M. (2019) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20193662 · Cited by 1

Dermatological Toxicities of Targeted Therapy

Pansare, R., Nagasaka, M., & Sukari, A. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-67241-2.00015-x · Cited by 1

Physiologically-based pharmacokinetic scaling in retinoid developmental toxicity

Willhite, C. C., & M.A., H. J. C. I. (2000) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8454-9_10 · Cited by 1

Dermatotherapeutic Agents

Gendimenico, G. J. (2006) · Ullmann's Encyclopedia of Industrial Chemistry · doi:10.1002/14356007.a08_301.pub2 · Cited by 1

Dermatotherapeutic Agents

Gendimenico, G. J. (2015) · Ullmann's Encyclopedia of Industrial Chemistry · doi:10.1002/14356007.a08_301.pub3 · Cited by 1

Retinoids and combination therapy

Cunliffe, W. J. (2000) · Journal of Dermatological Treatment · doi:10.1080/095466300750163663

Synthesis and Characterization of Novel 4-Hydroxy-(4-solanesylaminophenyl ) Retinoate

Yu, A. H., Tan, P., Deng, Q., Xiang, J. N., & Cao, Z. Y. (2011) · Advanced materials research · doi:10.4028/www.scientific.net/amr.236-238.2794

Aktuelle Vorstellungen zur Entstehung von Komedonen (Komedogenese) und Implikationen für eine Pathogenese-orientierte Aknetherapie

Jansen, T., Dissemond, J., & Grabbe, S. (2005) · Aktuelle Dermatologie · doi:10.1055/s-2005-870171

A Comparative Study to Evaluate the Efficacy and Safety of Topical Isotretinoin and Clindamycin Versus Adapalene and Clindamycin in The Treatment of Grade I - II Acne Vulgaris of Face

Adhikary, J., Satyanarayana, Bhandare, B., & Rajeswari, R. (2014)

LA TERAPIA CON RETINOIDES EN ACNÉ VULGAR

Vinhal, D. C., Roberth, A. O., Ortence, V. O. P., & Diniz, D. G. A. (2014)

Akne in der Pubertät: Abwarten, vorsichtig oder beherzt therapieren?

Meigel, W. (1999) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-662-01058-7_19

Observational study to see efficacy and Safety profile of Benzoyl peroxide 2.5%, Adapalene 0.1% and its fixed dose combination in mild to moderate grade of Acne Vulgaris

Mahendra, A. (2017) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v5i11.79

Study of the spectroscopic properties and deprotonation of 6-bromo-2-naphthoic acid

Ushakou, D. V., & Wróblewski, T. (2019) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117854

A Pharmacovigilance Study of Topical Acne Monotherapy with 0.1% Adapalene, and A Molecular Analytical Review of Adapalene in Evidence-Based Dermatopharmacological Treatment

Hazra, M. (2021) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2021.v70i02.032

Retinoids

Dawson, M. I. (2010) · Wiley eBooks · doi:10.1002/0471266949.bmc065.pub2

Topical Retinoids

Kroshinsky, D., & Shalita, A. R. (2007) · Basic and clinical dermatology · doi:10.3109/9781420018417.009

Dermatotherapeutic Agents

McGuire, J. L., Gendimenico, G. J., Cauwenbergh, G. F. M. J., & Mezick, J. A. (2000) · Ullmann's Encyclopedia of Industrial Chemistry · doi:10.1002/14356007.a08_301

A Vitamin Treatment for Motor Neurone Disease

Baptie, A., & McCaffery, P. J. A. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-55489-6_14

Adapalene

Bubna, A. K. (2025) · Springer eBooks · doi:10.1007/978-981-95-3803-4_4

FORMULATION AND EVALUATION OF INVASOMAL GEL OF ADAPALENE FOR EFFECTIVE ACNE TREATMENT

Singhai, M., & Kori, M. L. (2025) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2025v18i8.55143

Comparative Efficacy and Safety of Non-Cryotherapy Treatments Versus Cryotherapy for Plantar Warts: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Alabdulqader, A. A., Alkhudairy, S., Alwahabi, A. S. M., Alsulaiman, R. I., AlZubaidi, H. A. A., Alshammari, R. T., Dabat, L. M. A., Alqahtani, N. A., Alhamdan, M. J., Bakr, A., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15187071

AKNE VULGARİS TEDAVİSİ VE RETİNOİK ASİT TÜREVLERİ

Tari, O., & Tari, G. (2026) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1712057

RePurpose: An LLM-Assisted, Source-Traceable Drug Repurposing Tool with Retrospective Validation on Clemastine in Multiple SclerosisPreprint

Nayagam, N., & Arun, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.14.759218

Pharmacology of adapalene

MichelL, Jomard, & Démarchez (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.1390s2003.x · Cited by 106

Adapalene for the treatment of acne vulgaris

Weiss, J., & Shavin, J. S. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70445-1 · Cited by 18

Adapalene, a New Chemical Entity with Retinoid Activity

Bernard, B. A. (2009) · Skin Pharmacology · doi:10.1159/000211165 · Cited by 64

A New Concept of Drug Delivery for Acne

Shroot, B., Michel, S., Allec, J., Chatelus, A., & Wagner, N. (1998) · Dermatology · doi:10.1159/000017854 · Cited by 6

Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne

Czernielewski, J., Michel, S., Bouclier, M., Baker, M., & Hensby, C. N. (2001) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.0926-9959.2001.00006.x · Cited by 83