The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently
Abstract
Decreased levels of cerebrospinal fluid (CSF) Abeta42 is a diagnostic marker of Alzheimer's disease. To clarify the biological basis of this marker, the physiological alterations of CSF Abeta40 and Abeta42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a specific ELISA for Abeta40 and Abeta42(43). High concentrations of Abeta40 and Abeta42(43) in the young group, under 29 years old, changed to be at low concentrations in the adult group between 30 and 59 years old. Subsequently, the levels increased again with age. Third order regression analysis showed a significant correlation between the levels of Abeta40 and age (Y = - 169 X(3) + 3.1X(2)- 0.02X + 4135; P < 0.034) and between the levels of Abeta42(43) and age (Y = - 46 X(3) + 0.9 X(2)- 0.005X + 992; P < 0.005). The levels of CSF Abeta40 and Abeta42(43) were physiologically regulated to show a U-shaped natural course in normal aging. These findings suggested that the physiological increase of Abeta42(43) over 59 years of age is selectively inhibited in Alzheimer's disease.
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Normal age-related CSF Aβ levels vary with age; CSF Aβ levels seem to decline during young adulthood, and during late mid-life may slightly increase.
“Studies of non-demented individuals report that while CSF Aβ levels seem to decline during young adulthood, during late mid-life CSF Aβ levels may actually slightly increase [219, 220].”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [219]
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References 32 · Cited by 50
- Authors
- Shoji, M., Kanai, M., Matsubara, E., Tomidokoro, Y., Shizuka, M., Ikeda, Y., Ikeda, M., Harigaya, Y., Okamoto, K., & Hirai, S.
- Affiliations
- Gunma University (JP)
- Tokyo Metropolitan Neurological Hospital (JP)
- Corresponding author
- Shoji, M.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 22
- Issue
- 2
- Pages
- 209-215
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1985299119
- Cited by
- 50
- References
- 32
- Citations by year
- 2023: 3 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (12670593,12670592)
- Ministry of Health, Labour and Welfare
- Novartis Foundation
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Chiyoda Mutual Life Foundation
- MSD Life Science Foundation, Public Interest Incorporated Foundation
- Uehara Memorial Foundation
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- cerebrospinal fluid, Aβ40, amyloid-beta 42, aging, age-dependent regulation, Alzheimer's disease biomarkers, U-shaped curve
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Child, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Peptide Fragments, Regression Analysis, Amyloid beta-Peptides, Disease Progression
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