Cited by 281Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsCoenzyme Q10 studies and effects

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Cytochrome c oxidase is decreased in Alzheimer’s disease platelets

Cardoso, Sandra Morais, Proença, M.Teresa, Santos, Sancha, Santana, Isabel, Oliveira, Catarina R·2004·Neurobiology of Aging

DOI 10.1016/s0197-4580(03)00033-2

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Abstract

Cytochrome c oxidase (COX) activity reportedly is reduced in Alzheimer's disease (AD) brain and platelets. The reasons for the defect in either tissue are unknown, but its presence in a non-degenerating tissue suggests it is not simply a consequence of neurodegeneration. We now offer confirmation of the AD platelet COX defect. Compared to age-matched controls, in mitochondria isolated from AD platelets there was a 15% decrease in COX activity despite the fact that COX subunits were present at normal levels. Platelet ATP levels were diminished in AD (from 11.33 +/- 0.52 to 9.11 +/- 0.72 nmol/mg), while reactive oxygen species (ROS) were increased (from 97.03 +/- 25.9 to 338.3 +/- 100 K/mg). Platelet membrane fluidity, Vitamin E, and cholesterol content were similar between groups. We conclude that COX catalytic activity is indeed diminished in AD platelet mitochondria, does not result from altered membrane fluidity, and is associated with ROS overproduction and ATP under-production.

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Authors: Cardoso, S. M., Proença, M. T., Santos, S., Santana, I., & Oliveira, C. R.
Affiliations: University of Coimbra (PT)
Unidade Local de Saúde de Coimbra (PT)
Corresponding author: Oliveira, Catarina R
ORCID: Cardoso, Sandra Morais
Santana, Isabel
Oliveira, Catarina R
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2004-01
Volume: 25
Issue: 1
Pages: 105-110
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(03)00033-2
OpenAlex: W2072453593
Cited by: 281
References: 38
Citations by year: 2026: 9 · 2025: 11 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 16 · 2020: 14 · 2019: 16 · 2018: 7 · 2017: 9 · 2016: 14 · 2015: 10 · 2014: 13 · 2013: 22 · 2012: 17
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Keywords: cytochrome c oxidase, Alzheimer's disease, platelets, mitochondrial dysfunction, ATP production, reactive oxygen species, platelet mitochondria, platelet membrane fluidity, vitamin E, cholesterol
MeSH terms: Adenine Nucleotides, Adenosine Triphosphate, Aged, Alzheimer Disease, Blood Platelets, Cholesterol, Chromatography, High Pressure Liquid, Citrate (si)-Synthase, Electron Transport Complex IV, Free Radicals, Humans, Middle Aged, Mitochondria, NADP, Succinate Cytochrome c Oxidoreductase, Vitamin E, Electrophoresis, Gel, Two-Dimensional, Case-Control Studies, Age of Onset, Electron Transport Complex I

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Cytochrome c oxidase is decreased in Alzheimer’s disease platelets

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