Prevalence, incidence and duration of Braak's stages in the general population: can we know?
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The simple presence of plaques and tangles do not distinguish demented from non-demented individuals because brains of non-demented individuals frequently contain plaques and tangles.
“In addition, the simple presence of plaques and tangles do not distinguish demented from non-demented individuals because brains of non-demented individuals frequently contain plaques and tangles.”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [56]
For tau biomarkers, there is a strong discrepancy between neuropathological identification (tau Braak stages I-II almost universal after age 70) and in-vivo measures of tau aggregates on PET (36% of individuals are tau positive after age 70).
“For tau biomarkers, there is also a strong discrepancy between neuropathological identification (in post-mortem studies, the presence of tau Braak stages I–II is almost universal after age 70 years)17,19 and in-vivo measures of tau aggregates on PET (36% of individuals are tau positive after the age of 70 years23).”
From Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group (2021) · cites this paper as [19]
Neurofibrillary pathology is observed in the human brain long before Aβ plaques develop.
“Neurofibrillary pathology is observed in the human brain long before Aβ plaques develop (39, 44, 300).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [300]
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References 36 · Cited by 109
- Authors
- Duyckaerts, C., & Hauw, J.-J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Duyckaerts, C
- ORCID
- Duyckaerts, C
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 18
- Issue
- 4
- Pages
- 362-369
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2071134735
- Cited by
- 109
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 13 · 2014: 9 · 2013: 4 · 2012: 7
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Braak staging, neurofibrillary tangles, Alzheimer's disease, prevalence, incidence, disease duration, general population, neuropathology
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Brain Diseases, Cerebral Cortex, Dementia, Humans, Middle Aged, Research Design, Incidence, Prevalence, Amyloid beta-Peptides, Neurofibrillary Tangles, Disease Progression, Plaque, Amyloid
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