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Cited by 116Hepatitis B Virus StudiesHepatitis Viruses Studies and EpidemiologyTravel-related health issues

The DOI matches its Crossref record; 33 of the 38 references it cites were found in a registry or an index.

Immunogenicity of combined hepatitis A and B vaccine in elderly persons

Wolters, Bernd, Junge, Ulrich, Dziuba, Stefan, Roggendorf, Michael·2003·Vaccine
DOI 10.1016/s0264-410x(03)00399-2
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Abstract

More and more elderly people travel to areas where hepatitis A and B are endemic. Their immune system is less effective than in young persons. Therefore, it has to be insured that these travelers have protective immunity after vaccination. In a retrospective study we measured anti hepatitis virus (anti-HAV) and anti-HBs in elderly persons (N = 104, mean age 54 years) after combined hepatitis A/B vaccination under every-day conditions. After complete vaccination only 36 (34.6%) had antibodies against both viruses. Only 23 (29%) of 80 vaccinees older than 40 years were protected against hepatitis B and 52 (65%) against hepatitis A. The response to the vaccination decreased with increasing age. Vaccination against hepatitis B-but not against hepatitis A-was also influenced by the presence of chronic disease. After one booster 87% of the anti-HAV negative vaccinees developed protective anti-HAV antibodies. Anti-HBs can be expected in about 50% of the HBV negative vaccinees with every single booster. These results indicate that combined hepatitis A/B vaccination is not very effective in elderly persons. After complete vaccination their anti-HAV and anti-HBs antibodies have to be controlled to insure protection. In case of vaccination-failure boosters are very effective.

Overview

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Crossref · 10.1016/s0264-410x(03)00399-2

Cites

33 of 33 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. FDA approval for a combined hepatitis A and B vaccine. MMWR Morb Mortal Wkly Rep 2001;50:806–7.
  2. Keystone J, Parsons J, Anstey R. Reactogenicity and immunogenicity of a combined vaccine against hepatitis A and B in older adults. In: Proceedings of the Ninth Triennial International Symposium on Viral Hepatitis and Liver Disease, Rome, 21–25 April 1996, C324.
  3. Hofmann, 1997, Zur Effizienz der Hepatitis B-Schutzimpfung, Gesundheitswesen, 59, 527

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Metadata

Authors
Wolters, B., Junge, U., Dziuba, S., & Roggendorf, M.
Affiliations
  • University of Duisburg-Essen (DE)
  • Klinikum Bielefeld (DE)
Corresponding author
Roggendorf, Michael
ORCID
Roggendorf, Michael
Venue
Vaccine
Publisher
Elsevier BV
Published
2003-09
Volume
21
Issue
25-26
Pages
3623-3628
ISSN
0264-410X (ISSN-L)
DOI
10.1016/s0264-410x(03)00399-2
OpenAlex
W1980161689
Cited by
116
References
38
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 10 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 10
FWCI
6.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Vaccine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
  • Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
Keywords
immunogenicity, older adults, anti-HAV antibodies, anti-HBs antibodies, vaccine response, booster vaccination, vaccine failure, chronic disease, travel vaccination, age-related immune decline
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Female, Health Status, Hepatitis B Surface Antigens, Humans, Immunization Schedule, Immunization, Secondary, Male, Middle Aged, Retrospective Studies, Hepatitis B Vaccines, Vaccines, Combined, Hepatitis A Vaccines, Hepatitis A Antibodies

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