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Cited by 270

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses

Open access
Treanor, John J, Kotloff, Karen, Betts, Robert F, Belshe, Robert, Newman, Fran, Iacuzio, Dominick, Wittes, Janet, Bryant, Martin·1999·Vaccine
DOI 10.1016/s0264-410x(99)00334-5
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Abstract

Trivalent, live, cold-adapted influenza vaccine (CAIV-T) is highly effective in the prevention of influenza in children, and a variety of monovalent and bivalent cold-adapted influenza vaccines have been efficacious in adults. In order to determine the efficacy of CAIV-T in healthy adults, we administered CAIV-T, trivalent inactivated influenza vaccine (TIV) or placebo to 103 adults in randomized double-blind fashion, and then challenged those subjects who had pre-screening serum hemagglutination-inhibition antibody titers of 1:8 or less with wild-type influenza viruses corresponding to the strains contained in the vaccine. CAIV-T was well tolerated. Upon challenge with wild-type influenza virus, laboratory documented influenza illness (respiratory symptoms with either isolation of wild-type influenza virus from nasal secretions or 4-fold and/or greater HAI antibody response to challenge) occurred in 14/31 (45%) placebo recipients, 4/32 (13%) TIV recipients, and 2/29 (7%) CAIV-T recipients. The estimated protective efficacy of CAIV-T was therefore 85% and of TIV was 71%. These results are consistent with those of previous studies using monovalent preparations of cold-adapted influenza vaccine in this model, and indicate that CAIV-T will be an effective means to prevent influenza illness in adults.

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Metadata

Authors
Treanor, J. J., Kotloff, K., Betts, R. F., Belshe, R., Newman, F., Iacuzio, D., Wittes, J., & Bryant, M.
Venue
Vaccine
Publisher
Elsevier BV
Published
1999-12
Volume
18
Issue
9-10
Pages
899-906
ISSN
0264-410X (ISSN-L)
DOI
10.1016/s0264-410x(99)00334-5
OpenAlex
W1994815114
Cited by
270
References
17
FWCI
6.12
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses. https://app.cochat.ai/papers/10.1016/s0264-410x(99)00334-5
The paper
Treanor, J. J., Kotloff, K., Betts, R. F., Belshe, R., Newman, F., Iacuzio, D., Wittes, J., & Bryant, M. (1999). Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses. Vaccine. https://doi.org/10.1016/s0264-410x(99)00334-5

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.