The DOI matches its Crossref record; 26 of the 30 references it cites were found in a registry or an index.
Lipoprotein Glomerulopathy: Glomerular Lipoprotein Thrombi in a Patient With Hyperlipoproteinemia
Abstract
An unusual nephropathy presumably induced by abnormal lipid metabolism is described in a 57-year-old woman who presented with proteinuria and edema. Histology at renal biopsy was characterized by marked dilatation of capillary lumina. Sudan staining and electron microscopy demonstrated lipid droplets occupying the capillary lumina. The patient had no particular clinical symptoms of lipidosis, but hyperlipoproteinemia similar to type III was suggested by lipid profiles. The nephropathy is thought to be an inherited disorder because proteinuria was detected in her sisters and similar renal histology and lipid profile were observed in one of her sisters. This is believed to be the first detailed report of glomerular lipoprotein thrombi.
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In the citing paper
“Lipoprotein glomerulopathy (LPG) was initially reported in Japan [2] and later known to be associated with various heterozygous ApoE variants, e.g., ApoE Sendai [3] and ApoE Kyoto [4].”
From Membranous Nephropathy-Like Apolipoprotein E Deposition Disease with Apolipoprotein E Toyonaka (Ser197Cys) and a Homozygous Apolipoprotein E2/2 (2018) · cites this paper as [2]
In the citing paper
“Diagnosis of LPG relies primarily on renal pathology, with typical lipoprotein thrombosis within dilated glomerular capillary loops.”
From A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation (2024) · cites this paper as [1]
In the citing paper
“Lipoprotein glomerulopathy (LPG) is an inherited glomerular disease caused by mutations in the APOE gene, usually with clinical manifestations of dysregulated lipid metabolism, proteinuria, and renal insufficiency.”
From A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation (2024) · cites this paper as [1]
In the citing paper
“The first 2 cases of LPG were reported by Japanese scholar Saito et al. in the same family in 1989 [1].”
From A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation (2024) · cites this paper as [1]
In the citing paper
“Massive lipoprotein thrombi in the lumens of dilated glomerular capillaries are the typical pathological manifestation of LPG3).”
From The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T＞C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy (2018) · cites this paper as [3]
In the citing paper
“In contrast to apoE2 homozygote glomerulopathy, LPG is characterized by dilation of glomerular capillaries with lipoprotein thrombi showing lamellar formation, directly inducing glomerular damage without inducing foamy changes68).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [68]
In the citing paper
“LPG is a rare renal disease first reported in Japan in 1989 68).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [68]
In the citing paper
“LPG was initially identified as a glomerular disease associated with type III HLP68).”
From Impact of Apolipoprotein E Variants: A Review of Naturally Occurring Variants and Clinical Features (2025) · cites this paper as [68]
In the citing paper
“Histological features are the most important evidence for the diagnosis of LPG [2].”
From A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports (2022) · cites this paper as [2]
In the citing paper
“Immunofluorescence microscopy shows positive staining of ApoE and ApoB in lumen thrombotic substances.”
From A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports (2022) · cites this paper as [2]
In the citing paper
“Nearly half of mutations occurred in the LDL-receptor binding site (LRBS), such as ApoE Sendai (Arg145Pro) [2], ApoE Chicago (Arg147Cys) [16], ApoE Guangzhou (Arg150Pro)[17], ApoE Modena (Arg 150Cys) [11], ApoE Okayama (Arg150Gly) [18], ApoE Tokyo (Del 141-143) [19], and ApoE Maebasi (Del 142-144). These mutations might result in reduced binding capacity of ApoE protein to LDL receptor.”
From A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports (2022) · cites this paper as [2]
In the citing paper
“Under light microscopy, the capillary lumen is typically highly dilated and filled with lightly stained reticular material.”
From A novel apolipoprotein E mutation, ApoE Ganzhou (Arg43Cys), in a Chinese son and his father with lipoprotein glomerulopathy: two case reports (2022) · cites this paper as [2]
In the citing paper
“Lipoprotein glomerulopathy (LPG) is a rare inherited disease characterized by histopathological features of lipoprotein thrombi in dilated glomerular capillaries and type III like hyperlipoproteinemia with heterozygous mutation of the apolipoprotein (apo) E gene.”
From A case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I (2018) · cites this paper as [1]
In the citing paper
“Lipoprotein glomerulopathy (LPG) is a condition first described in Japan in 1989.1”
From Lipoprotein Glomerulopathy, First Case Report from Canada (2022) · cites this paper as [1]
Citations
Cites
Hatch, F. T., & Lees, R. S. (1968) · Advances in lipid research · doi:10.1016/b978-1-4831-9942-9.50008-5 · Cited by 1,235
Renal Disease. Classification and Atlas of Glomerular Diseases.
(1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-97-5-801_2 · Cited by 675
Apolipoprotein E polymorphism in health and disease
Utermann, G. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90610-7 · Cited by 389
LACTIC ACIDOSIS AND HYPERLACTATÆMIA
Cohen, R. D., Woods, H. F., & Alberti, K. G. M. M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91784-x · Cited by 222
Type III Hyperlipoproteinemia: An Analysis of Two Contemporary Definitions
Fredrickson, D. S., MORGANROTH, J., & LEVY, R. I. (1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-82-2-150 · Cited by 177
Bouthillier, D., Sing, C. F., & Davignon, J. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37920-7 · Cited by 176
The clinical spectrum of renal cholesterol embolization
Smith, M. C. F., Ghose, M., & Henry, A. R. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90290-4 · Cited by 147
Hazzard, W. R., Porte, D., & Bierman, E. L. (1972) · Metabolism · doi:10.1016/0026-0495(72)90031-5 · Cited by 134
The Progressive nature of renal disease
Mitch, W. E. (1986) · Churchill Livingstone eBooks · Cited by 131
Grond, J., Weening, J. J., & Elema, J. D. (1984) · PubMed · Cited by 107
Research works printed but not linked: 2
- Hatch, 1986, Practical methods for plasma lipoprotein analysis, Adv Lipid Res, 6, 1
- Amatruda, 1974, Type III hyperlipoproteinemia with mesangial foam cells in renal glomeruli, Arch Pathol, 98, 51
Cited by
Sorted by citations
Items 101–148 of 148
Hereditary Serum Cholinesterase Deficiency Associated with Severe Lipid Deposition in the Kidney.
Honda, K., Yumura, W., Arai, J. A., Sanaka, T., Nihei, H., & Sugino, N. (1993) · Internal Medicine · doi:10.2169/internalmedicine.32.145 · Cited by 5
Kuge, Y., Nozaki, S., 北河, 亜., Inoue, T. K., Otsuka, H., & Ito, Y. (2004) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.11.293 · Cited by 5
Kashtan, C. E., & Gübler, M.-C. (2009) · Springer eBooks · doi:10.1007/978-3-540-76341-3_26 · Cited by 5
Case Report: A Pediatric Case of Lipoprotein Glomerulopathy in China and Literature Review
Song, Y., Yang, C., Liu, L., & Wang, H. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.684814 · Cited by 5
Intravascular cardiac lipoproteinosis: extrarenal manifestation of lipoprotein glomerulopathy
Morris, C. S., Bois, M. C., Aust, C. H., Thomas, R., Sethi, S. M., & Maleszewski, J. J. (2019) · Cardiovascular Pathology · doi:10.1016/j.carpath.2019.04.006 · Cited by 4
Case Report: Lipoprotein Glomerulopathy Complicated by Atypical Hemolytic Uremic Syndrome
Kollbrunner, L., Hirt‐Minkowski, P., Sanz, J., Bresin, E., Neuhaus, T. J., Hopfer, H., & Jehle, A. W. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.679048 · Cited by 4
A case of diagnosing lipoprotein glomerulopathy in Russia
Сиповский, В. Г., Klemina, I., Зверьков, Р. В., Dobronravov, V., & Smirnov, A. V. (2016) · Russian Journal of Archive of Pathology · doi:10.17116/patol201678652-57 · Cited by 4
Kuribayashi‐Okuma, E., Shibata, S., Arai, S., Ota, T., Watanabe, S. T., Hisaki, H., Okazaki, T., Toda, T., & Uchida, S. (2016) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.12356 · Cited by 3
Genetic Analysis of Intracapillary Glomerular Lipoprotein Deposits in Aging Mice
Noordmans, G. A., Huang, Y., Savage, H. S., van Dijk, M. C. R. F., Schaart, G., Weerman, M. A. V. D. B., Heeringa, P., Hillebrands, J., Korstanje, R., & van Goor, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111308 · Cited by 3
Abe, T., Kondo, T., Suzuki, A., Yamamoto, H., WATANABE, N., KURODA, R., Fukazawa, Y., & Kawakami, Y. (1992) · Internal Medicine · doi:10.2169/internalmedicine.31.44 · Cited by 3
A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation
Liu, Y., Cheng, Y., Wen, Y., Li, C., Chen, G., & Li, M. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03515-z · Cited by 2
A boy and his mother with lipoprotein glomerulopathy: Two case reports and literature review
Zhang, S., Fan, L., Li, Z., Liu, T., Jing, X., & Guo, Q. (2025) · Medicine · doi:10.1097/md.0000000000041628 · Cited by 2
Normolipidemic lipoprotein glomerulopathy with IgA nephropathy — ApoE Kyoto mutation: a case report
Yi, X., Bai, L., Chen, K., He, Y., & Chen, J. (2025) · Diagnostic Pathology · doi:10.1186/s13000-025-01636-z · Cited by 2
Ullur, A. R., Ávila-Casado, C., Agrawal, V., & Kaushal, A. (2023) · Journal of Nephrology · doi:10.1007/s40620-023-01653-5 · Cited by 2
Lipoprotein glomerulopathy in China
Chen, Y. (2013) · Clinical and Experimental Nephrology · doi:10.1007/s10157-013-0873-x · Cited by 2
Posttransplant proteinuria due to Apolipoprotein E2 deposition in a kidney allograft
Ramakrishnan, M., Fields, T. A., Zhang, D., Owoyemi, I. O., Gupta, A., Klein, J. A., Herrera, N. S., Gupta, M., & Cibrik, D. M. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16774 · Cited by 2
Enfermedades glomerulares secundarias
Fogo, A. B., & Kashgarian, M. J. (2006) · Elsevier eBooks · doi:10.1016/b978-84-8174-959-5.50013-2 · Cited by 2
New Cases of Lipoprotein Glomerulopathy?
Grcevska, L., Polenakovic, M. H., Milovanceva-Popovska, M., & Petruševska, G. (2000) · The Nephron journals/Nephron journals · doi:10.1159/000045872 · Cited by 2
Renal Disease in an Adult Patient with Type I Glycogen Storage Disease
Lim, P., & Kho, B. (1995) · Renal Failure · doi:10.3109/08860229509037646 · Cited by 1
Kato, J., Okonogi, H., Kanzaki, G., Katsumata, H., Nakada, Y., Sagasaki, M., Komine, K., Ito, K., Saito, T., Matsunaga, A., et al. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03612-z · Cited by 1
Self-citationSampietro, T., Sbrana, F., Pino, B. D., MIGLIORI, M., Bruno, S., Grange, C., Bussolati, B., Camussi, G., Grossini, E., Bigazzi, F., et al. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.04.027 · Cited by 1
Masakane, I., Hanafusa, N., Miyazaki, M., Hoshino, J., & Nishida, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-56890-0_25 · Cited by 1
Genetic Causes of Chronic Kidney Disease
Hall, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-52978-5.00007-0 · Cited by 1
Cheung, C. Y., & Lau, W. H. (2022) · Journal of clinical lipidology · doi:10.1016/j.jacl.2021.12.003 · Cited by 1
Fogo, A. B., & Kashgarian, M. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0427-3.00001-5 · Cited by 1
Renal Diseases and Abnormal Lipid Metabolism
Okubo, M., Kobayashi, N., Nakamura, M., & Naito, M. (2006) · Journal of Rural Medicine · doi:10.2185/jrm.1.2_13 · Cited by 1
SPONTANEOUS LIPOPROTEIN GLOMERULOPATHY-LIKE NEPHROPATHY IN A SQUIRREL (SCIURUS VULGARIS)
Kobayashi, R., CHAMBERS, J. K., Yoshida, K., Nakamura, T., Yasuno, K., Uchida, K., Kamiie, J., & Shirota, K. (2016) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2015-0245.1 · Cited by 1
Fogo, A. B., & Kashgarian, M. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-39053-8.00003-4 · Cited by 1
Thrombotic microangiopathy and their mimickers
Palma, L. M. P., & Sethi, S. M. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa230 · Cited by 1
Patient with lipoprotein glomerulopathy complicated with central retinal artery obstruction.
武生, 小., 佳典, 藤., 弘之郎, 槇., & 金津, 和. (1995) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.84.1332 · Cited by 1
内科 １００年のあゆみ 腎臓 ＩＩ 日本人の貢献 ７ Ｌｉｐｏｐｒｏｔｅｉｎ ｇｌｏｍｅｒｕｌｏｐａｔｈｙ
喬雄, 斉. (2002) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.91.1444 · Cited by 1
Identification of a founder haplotype of APOE Kyoto variant in lipoprotein glomerulopathy
Wu, H., He, Z., Yang, J., Zhou, Y., Yang, Z., Hu, Z., & Yang, Y. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf234
The First Case of Lipoprotein Glomerulopathy in a Patient With Male Infertility
Ye, C., Wang, Y., Liang, C., Wang, Y., Zhang, C., & Jiang, H. (2026) · Kidney Medicine · doi:10.1016/j.xkme.2026.101308
Microalbuminuria in Essential Hypertension. Significance for the Cardiovascular and Renal Systems
Campese, V. M., Bigazzi, R., & Bianchi, S. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4499-9_43
The Case ∣ An Asian boy with proteinuria
Chen, H., Liu, Z., & Leishi, L. (2008) · Kidney International · doi:10.1038/ki.2008.296
Peculiar Membranogranular Glomerular Deposits
Min, K. (1994) · Ultrastructural Pathology · doi:10.3109/01913129409016285
A new variant of apolipoprotein E in a girl with lipoprotein glomerulopathy.
Ogawa, T., Arai, H., Watanabe, T., Kobayashi, Y., Morikawa, A., Maruyama, K., Hattori, H., & Egashira, T. (1998) · Japanese journal of pediatric nephrology · doi:10.3165/jjpn.11.171
Síndrome nefrótico asociado a mutación de la apolipoproteína-E. ¿Nueva entidad clínica?
de Anda, R. G., & Casados, M. D. C. A. (2012)
[A case of lipoprotein glomerulopathy and a literature review of the subject].
Hu, H., & Zhang, X. (2012) · PubMed · doi:10.3969/j.issn.1672-7347.2012.03.020
Disease state of lipoprotein glomerulopathy.
斉藤, 喬. (2006) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.95.1838
KIDNEY BIOPSY TEACHING CASE A Rare Cause of Posttransplantation Nephrotic Syndrome
Foster, K. W., Matsunaga, A., Matalon, R., Saito, T., Gallo, G., & Stokes, M. B. (2005)
Self-citationRheault, M. N., & Kashtan, C. E. (2014) · Springer eBooks · doi:10.1007/978-3-642-27843-3_79-1
APOE Lipoprotein Glomerulopathy
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37707-2.50086-0
Glomerular Diseases—Hereditary
Fischer, E. G., Cerilli, L. A., & Lager, D. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06966-6.00008-8
Apolipoprotein E Dyslipidemia and Nephrotic Syndrome: A Rare Connection
Tito, S., Atri, A., Patil, S. P., Dean, S., & Carpenter, S. (2023) · Annals of Internal Medicine Clinical Cases · doi:10.7326/aimcc.2023.0059
Apo E Variant (Apo E Sendai) and Lipoprotein Glomerulopathy
OIKAWA, S.-I., Hoshi, K., Hayasaka, K., MIDORIKAWA, H., Sekikawa, A., Toyota, T., Saito, T., Matsunaga, A., & SASAKI, J. (1997) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.24.10_523
Self-citationA case of normolipidemic lipoprotein glomerulopathy due to the APOE Kyoto variant
Xu, J., Zou, W., Lin, B., Zhu, B., & Gong, J. (2026) · Journal of clinical lipidology · doi:10.1016/j.jacl.2026.05.229
A case of lipoprotein glomerulopathy in which complete remission was achieved by pemafibrate therapy
Tomita, C., Sato, T., Suzuki, Y., Arakawa, M., Shimizu, Y., Suzuki, Y., Yasuda, H., & Misaki, T. (2026) · CEN Case Reports · doi:10.1007/s13730-026-01148-9
Metadata
- Authors
- Saito, T., Sato, H., Kudo, K.-I., Oikawa, S.-I., Shibata, T., Hara, Y., Yoshinaga, K., & Sakaguchi, H.
- Affiliations
- Tohoku University (JP)
- Corresponding author
- Saito, Takao
- Venue
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 13
- Issue
- 2
- Pages
- 148-153
- ISSN
- 0272-6386 (ISSN-L)
- OpenAlex
- W1964757582
- Semantic Scholar
- da403efad9eaea0bf6dbcbfdb6bf2659875fab39
- Cited by
- 148
- References
- 30
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Kidney Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- lipoprotein glomerulopathy, type III hyperlipoproteinemia, familial hypercholesterolemia, proteinuria, lipid metabolism disorders, renal biopsy histology
- MeSH terms
- Adult, Capillaries, Female, Humans, Hyperlipoproteinemias, Immunoglobulin G, Immunoenzyme Techniques, Kidney Diseases, Kidney Glomerulus, Lipoproteins, LDL, Middle Aged, Sclerosis, Thrombosis
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