The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Substance use disorders in schizophrenia: review, integration, and a proposed model
Abstract
Substance use disorders occur in approximately 40 to 50% of individuals with schizophrenia. Clinically, substance use disorders are associated with a variety of negative outcomes in schizophrenia, including incarceration, homelessness, violence, and suicide. An understanding of the reasons for such high rates of substance use disorders may yield insights into the treatment of this comorbidity in schizophrenia. This review summarizes methodological and conceptual issues concerning the study of substance use disorders in schizophrenia and provides a review of the prevalence of this co-occurrence. Prevailing theories regarding the co-occurrence of schizophrenia and substance use disorders are reviewed. Little empirical support is found for models suggesting that schizophrenic symptoms lead to substance use (self-medication), that substance use leads to schizophrenia, or that there is a genetic relationship between schizophrenia and substance use. An integrative affect-regulation model incorporating individual differences in traits and responses to stress is proposed for future study.
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“In their model, Blanchard et al. (30) suggest that individuals with certain personality traits (i.e., negative affectivity/neuroticism and disinhibition/impulsivity) who also show difficulties in applying effective coping methods (e.g., interpersonal problem-solving) are more at risk of using substances to cope with negative emotion when encountering important stresses.”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [30]
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Cites
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Chassin, L., Pitts, S. C., & Prost, J. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.1.67 · Cited by 766
Barrowclough, C., Haddock, G., Tarrier, N., Lewis, S. W., Moring, J., O’Brien, R., Schofield, N., & McGovern, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1706 · Cited by 535
The social and economic burden of treatment-resistant schizophrenia: a systematic literature review
Kennedy, J. L., Altar, C. A., Taylor, D. L., Degtiar, I., & Hornberger, J. C. (2014) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32836508e6 · Cited by 392
Lambert, M., Conus, P., Lubman, D., Wade, D., Yuen, H. P., Moritz, S., Naber, D., McGorry, P., & Schimmelmann, B. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00554.x · Cited by 349
Affective traits in schizophrenia and schizotypy
Horan, W. P., Blanchard, J. J., Clark, L. A., & Green, M. F. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn083 · Cited by 290
Self-citation
Metadata
- Authors
- Blanchard, J.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- Blanchard, J
- ORCID
- Blanchard, J
- Venue
- Clinical Psychology Review
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 20
- Issue
- 2
- Pages
- 207-234
- ISSN
- 0272-7358 (ISSN-L)
- OpenAlex
- W2040936438
- Cited by
- 240
- References
- 169
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 15 · 2012: 11
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Psychology Review (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH51240)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- substance use disorders, schizophrenia, comorbidities, self-medication, stress response, individual differences, genetic relatedness, prevalence, adverse outcomes, suicide, homelessness, incarceration
- MeSH terms
- Affect, Emotions, Humans, Models, Psychological, Schizophrenia, Comorbidity, Diagnosis, Dual (Psychiatry), Substance-Related Disorders
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