Effects of sodium valproate on synaptic plasticity in the CA1 region of rat hippocampus
Abstract
Sodium valproate (VPA) is currently one of the major anticonvulsant drug in clinical use and has a wide spectrum of antiepileptic activity. Previous studies have reported that VPA impairs long-term potentiation (LTP). In the present study, we used two forms of synaptic plasticity, LTP and long-term depression (LTD) of field excitatory postsynaptic potential (fEPSP) to investigate the effects of VPA on synaptic plasticity in rat hippocampal slices. Paired-pulse facilitation (PPF) and field EPSP were recorded in the CA1 area of hippocampal slices exposed to VPA. The results showed that: (1) three different concentrations of VPA (0.6, 1 and 5 mM) all induced a significant impairment of PPF at 20-150 ms inter-pulse intervals (IPI) (P 0.05). These results suggested that VPA impaired LTP and LTD. Furthermore, VPA-induced impairment of LTP could be correlated with the enhancement of inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA) receptor.
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Synaptic plasticity is the cellular and molecular basis of learning and memory.
“It constitutes the cellular and molecular basis of learning and memory and encompasses both functional forms of plasticity, such as long-term potentiation (LTP) and long-term depression (LTD), and structural remodeling of neuronal connectivity (Marrone and Petit, 2002; Zhang et al., 2003).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Zhang et al., 2003
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Endocrine disrupting effects on morphological synaptic plasticity
Zsarnovszky, A., Alymbaeva, D., Jocsak, G., Szabo, C., Mária Schilling-Tóth, B., & Sandor Kiss, D. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101157 · Cited by 7 · see citing works
Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
- Authors
- Zhang, M.-M., Xiao, C., Yu, K., & Ruan, D.-Y.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Ruan, Di-Yun
- ORCID
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 41
- Issue
- 11
- Pages
- 1617-1623
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2034218257
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- valproic acid, synaptic plasticity, long-term potentiation, long-term depression, hippocampal CA1, paired-pulse facilitation, GABAA receptor, picrotoxin, inhibitory neurotransmission, antiepileptic drugs, field excitatory postsynaptic potentials
- MeSH terms
- Animals, Anticonvulsants, Female, Hippocampus, Male, Neuronal Plasticity, Picrotoxin, Synapses, Valproic Acid, Rats, Wistar, Long-Term Potentiation, GABA Antagonists, Excitatory Postsynaptic Potentials, Rats, GABA-A Receptor Antagonists
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