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Cited by 135Gastrointestinal motility and disordersNeuropeptides and Animal PhysiologyCongenital gastrointestinal and neural anomalies

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Structural Organization and Neuropeptide Distribution in the Mammalian Enteric Nervous System, with Special Attention to Those Components Involved in Mucosal Reflexes

Timmermans, Jean-Pierre, Adriaensen, Dirk, Cornelissen, Wim, Scheuermann, Dietrich W·1997·Comparative Biochemistry and Physiology Part A: Physiology
DOI 10.1016/s0300-9629(96)00314-3
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Abstract

Gastrointestinal events such as peristalsis and secretion/absorption processes are influenced by the enteric nervous system, which is capable of acting largely independently from other parts of the nervous system. Several approaches have been used to further our understanding of the underlying mechanisms of specific enteric microcircuits. Apart from pharmacological and physiological studies, the deciphering of the chemical coding of distinct morphological and functional enteric neuron classes, together with a detailed analysis of their projections by the application of immunocytochemistry, of tracing, and of denervation techniques, have substantially contributed to our knowledge. In view of existing interspecies and regional differences, it is of major importance to expand our knowledge of the enteric nervous system in mammals other than the guinea-pig, the most commonly used experimental animal in this research area. This will increase our chances of finding a valid model, from which well-founded extrapolations can be made regarding the precise function of distinct enteric neuron types regulating motility and ion transport in the human gastrointestinal tract.

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  • The ENS is believed to be more analogous to the CNS than other networks within the peripheral nervous system.

    “Due to the organization and structure of the number, morphology, and neurochemical nature of the ENS networks within the ANS, it is believed to be more analogous to the CNS than other networks within the peripheral nervous system (Gershon, 2018;Timmermans et al., 1997;Wood, 2008Wood, , 2016)).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Timmermans et al., 1997

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Metadata

Authors
Timmermans, J.-P., Adriaensen, D., Cornelissen, W., & Scheuermann, D. W.
Affiliations
University of Antwerp (BE)
Corresponding author
Timmermans, Jean-Pierre
ORCID
Timmermans, Jean-Pierre
Venue
Comparative Biochemistry and Physiology Part A: Physiology
Publisher
Elsevier BV
Published
1997-10
Volume
118
Issue
2
Pages
331-340
ISSN
0300-9629 (ISSN-L)
DOI
10.1016/s0300-9629(96)00314-3
OpenAlex
W2033798970
Cited by
135
References
0
Citations by year
2026: 2 · 2023: 9 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
5.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Comparative Biochemistry and Physiology Part A Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords
enteric nervous system, neuropeptides, enteric neurons, gastrointestinal motility, ion transport, chemical coding, guinea pig model
MeSH terms
Animals, Humans, Intestinal Mucosa, Mammals, Nerve Net, Neurons, Neuropeptides, Reflex, Enteric Nervous System, Cell Size

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