The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease
Open accessAbstract
One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative stress hypothesis. The amyloid beta-peptide (A beta), a hallmark in the pathogenesis of AD and the main component of senile plaques, generates free radicals in a metal-catalyzed reaction inducing neuronal cell death by a reactive oxygen species mediated process which damage neuronal membrane lipids, proteins and nucleic acids. Therefore, the interest in the protective role of different antioxidants in AD such as vitamin E, melatonin and estrogens is growing up. In this review we summarize data that support the involvement of oxidative stress as an active factor in A beta-mediated neuropathology, by triggering or facilitating neurodegeneration, through a wide range of molecular events that disturb neuronal cell homeostasis.
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Oxidative stress is linked to amyloid-beta (Aβ) toxicity in AD.
“Oxidative stress is linked to amyloid-beta (Aβ) toxicity in AD [44,45].”
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References 196 · Cited by 369
- Authors
- Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- Corresponding author
- Inestrosa, Nibaldo C
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 62
- Issue
- 6
- Pages
- 633-648
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2017770853
- Cited by
- 369
- References
- 196
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 9 · 2018: 14 · 2017: 8 · 2016: 12 · 2015: 8 · 2014: 16 · 2013: 16 · 2012: 11
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative stress, amyloid-beta, Alzheimer's disease, reactive oxygen species, free radicals, metal-catalyzed oxidation, neurodegeneration, antioxidants, vitamin E, melatonin, estrogen, neuronal cell death, amyloid plaques, lipid peroxidation
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Humans, Membrane Lipids, Metals, Nucleic Acids, Proteins, Receptors, Cell Surface, Amyloid beta-Peptides, Cell Death, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents
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