CoChat
Sign Up
Cited by 481Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 1,258 of the 1,268 references it cites were found in a registry or an index.

Pharmacology and behavioral pharmacology of the mesocortical dopamine system

Tzschentke, T.M.·2001·Progress in Neurobiology
DOI 10.1016/s0301-0082(00)00033-2
Open this paper in CoChat — free account

Abstract

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the knowledge about the function of this brain area and the role it plays in cognitive performance and behavioral output. In the first part, this review provides, from a pharmacological perspective, an overview of anatomical, electrophysiological and neurochemical aspects of the function of the PFC, with an emphasis on the mesocortical dopamine system. Anatomy of the mesocortical system, basic physiological and pharmacological properties of neurotransmission within the PFC, and interactions between dopamine and glutamate as well as other transmitters within the mesocorticolimbic circuit are included. The coverage of these data is largely restricted to what is relevant for the second part of the review which focuses on behavioral studies that have examined the role of the PFC in a variety of phenomena, behaviors and paradigms. These include reward and addiction, locomotor activity and sensitization, learning, cognition, and schizophrenia. Although the focus of this review is on the mesocortical dopamine system, given the intricate interactions of dopamine with other transmitter systems within the PFC and the importance of the PFC as a source of glutamate in subcortical areas, these aspects are also covered in some detail where appropriate. Naturally, a topic as complex as this cannot be covered comprehensively in its entirety. Therefore this review is largely limited to data derived from studies using rats, and it is also specifically restricted to data concerning the medial PFC (mPFC). Since in several fields of research the findings concerning the function or role of the mPFC are relatively inconsistent, the question is addressed whether these inconsistencies might, at least in part, be related to the anatomical and functional heterogeneity of this brain area.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0301-0082(00)00033-2

Cites

1258 of 1258 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 1,268 references

Research works printed but not linked: 50

  1. Arvanitogiannis, 1997, Fos expression following self-stimulation of the medial prefrontal cortex, Soc. Neurosci. Abstr., 23, 2384
  2. Bauco, 1994, Extracellular nucleus accumbens dopamine and metabolite levels during earned and unearned lateral hypothalamic brain stimulation, Soc. Neurosci. Abstr., 20, 823
  3. Carr, G.D., Fibiger, H.C., Phillips, A.G., 1989. Conditioned place preference as a measure of drug reward. In: J.M. Liebman, S.J. Cooper (Eds.), The Neuropharmacological Basis of Reward. Clarendon Press, Oxford, pp. 264–319.
  4. Carter, 1980, Glutamatergic pathways from the medial pre-frontal cortex to the anterior striatum, nucleus accumbens and substantia nigra, Br. J. Pharmacol., 70, 50
  5. Carter, 1978, Studies on the roles of catecholamines in the frontal cortex, Br. J. Pharmacol., 62, 402P
  6. Childress, 1996, Brain correlates of cue-induced and opiate craving, Soc. Neurosci. Abstr., 22, 365.5
  7. Conover, 1992, Coactivation of the lateral hypothalamus and ventral tegmental area yields greater reward summation than coactivation of the lateral hypothalamus and medial pre-frontal cortex, Soc. Neurosci. Abstr., 18, 709
  8. Di Chiara, 1992, Heterologous monoamine uptake: lack of transmitter specificity of neuron-specific carriers, Neurochem. Int., 20, 231S
  9. Ditzler, 1991, Efficacy and tolerability of memantine in patients with dementia syndrome, Arzneimittelforschung/Drug Res., 8, 773
  10. Douglin, 1979, Gradual increases in self-stimulation response rates: effect of electrode loci, Physiol. Behav., 7, 135
  11. Feenstra, 1993, In vivo dopamine release in the rat prefrontal cortex is increased by stimulation of mediodorsal thalamic nucleus, Soc. Neurosci. Abstr., 19, 1382
  12. Feenstra, 1995, Local application of a competitive NMDA antagonist in the medial prefrontal cortex increases in vivo DA but not NA release, Br. J. Pharmacol., 114, 328P
  13. Forno, L.S., 1990. Pathology of Parkinson's disease: the importance of the substantia nigra and Lewy bodies. In: Stern, G. (Ed.), Parkinson's Disease. Chapman and Hall, London, pp. 185–238.
  14. Fuster, J., 1980. The prefrontal cortex. Raven Press, New York.
  15. Gabbott, 1996, Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey: II. Quantitative arial and laminar distributions, J. Comp. Neurol., 364, 609, 10.1002/(SICI)1096-9861(19960122)364:4<609::AID-CNE2>3.0.CO;2-7 · DOI
  16. Gillham, 1990, GABA neurons in the ventral tegmental area project to the medial prefrontal cortex: a non-dopaminergic mesocortical system, Soc. Neurosci. Abstr., 16, 105
  17. Grace, 1984, Electrophysiology and morphology of four classes of prefrontal neocortical neurons studied in vitro, Soc. Neurosci. Abstr., 10, 739
  18. Gresch, 1995, Stress-induced sensitization of dopamine and norepinephrine efflux in medial prefrontal cortex of the rat, J. Neurochem., 65, 575, 10.1046/j.1471-4159.1995.65010111.x · DOI
  19. Hemby, 1990, Neuropharmacological assessment of cocaine-induced conditioned place preference using intra-cranial microinjections, Soc. Neurosci. Abstr., 16, 243.6
  20. Hoffmann, 1986, Multiple effects of neuronal uptake inhibitors on transmitter release, J. Pharmacol. Exp. Ther., 238, 437
  21. Koob, G.F., Goeders, N.E., 1989. Neuroanatomical substrates of drug self-administration. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 214–236.
  22. Kuczenski, R., Segal, D.S., 1994. Neurochemistry of amphetamine. In: Cho, A., Segal, D.S. (Eds.), Amphetamine and its analogs. Academic Press, San Diego, pp. 81–113.
  23. Kurata, 1993, Differential effects of tight and loose 2-h restraint stress on extracellular concentrations of dopamine in nucleus accumbens and anteromedial frontal cortex, Jpn. J. Psychiatry Neurol., 47, 57
  24. Lindvall, O., Björklund, A., 1984. In: Descarries, L., Reader, T.R., Jasper, H.H. (Eds.), General organization of cortical monoamine systems. Liss, New York.
  25. Lu, 1997, Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area, Synapse, 25, 205, 10.1002/(SICI)1098-2396(199702)25:2<205::AID-SYN11>3.0.CO;2-X · DOI
  26. Moore, 1996, Interactions between amygdala and prefrontal cortical afferents to the nucleus accumbens and their modulation by dopamine receptor activation, Soc. Neurosci. Abstr., 22, 1088
  27. Moore, R.Y., Card, J.P., 1984. Noradrenaline-containing neuron systems. In: Björklund, A., Hökfelt, T. (Eds.), Handbook of Chemical Neuroanatomy, vol. 2. Elsevier, Amsterdam, pp. 123–156.
  28. Muly, 1997, D1 dopamine receptors are present in parvalbumine-positive interneurons in macaque prefrontal cortex, Soc. Neurosci. Abstr., 23, 1772
  29. Nishijima, 1996, Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis, Synapse, 22, 304, 10.1002/(SICI)1098-2396(199604)22:4<304::AID-SYN2>3.0.CO;2-F · DOI
  30. Nonneman, 1974, Comparisons of behavioral effects of hippocampal and prefrontal cortex lesions in the rat, J. Comp. Physiol. Psychol., 87, 249, 10.1037/h0036864 · DOI
  31. Palkovits, M., 1979. Dopamine levels of individual brain regions: biochemical aspects of DA distribution in the central nervous system. Academic Press, London, pp. 343–356.
  32. Phillips, A.G., Fibiger, H.C., 1989. Neuroanatomical bases of intracranial self-stimulation: untangling the Gordian knot. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 66–105.
  33. Pickel, V.M., Sesack, S.M., 1995. Electron microscopy of central dopamine systems. In: Bloom, F.E., Kupfer, D.J. (Eds.), Psychopharmacology: The fourth generation of progress. Raven Press, New York, pp. 257–268.
  34. Seamans, 1995, Selective impairment on a delayed radial arm task following local administration of a D1, but not a D2, antagonist into the prefrontal cortex, Soc. Neurosci. Abstr., 21, 1942
  35. Shibata, 1990, Effect of dopamine agonists on locomotor activity of anteromedial frontal cortex lesioned rats, Jpn. J. Psychiatry Neurol., 44, 789
  36. Shippenberg, 1993, Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D1 versus D2 dopamine receptors, J. Pharmacol. Exp. Ther., 265, 53
  37. Simon, 1981, Dopaminergic A10 neurons and the frontal system, J. Physiol., 77, 81
  38. Smiley, 1996, Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy, J. Comp. Neurol., 367, 431, 10.1002/(SICI)1096-9861(19960408)367:3<431::AID-CNE8>3.0.CO;2-6 · DOI
  39. Smith, 1998, Microcircuitry of the direct and indirect pathways of the basal ganglia, Neuroscience, 86, 353
  40. Stellar, J.R., Rice, M.B., 1989. Pharmacological basis of intracranial self-stimulation reward. In: Liebman, J.M., Cooper, S.J. (Eds.), The neuropharmacological basis of reward. Clarendon Press, Oxford, pp. 14–65.
  41. Taylor, 1978, Comparison of monoamine uptake by cocaine, methylphenidate and amphetamine, Res. Commun. Pathol. Pharmacol., 21, 67
  42. Thierry, A.M., Tassin, J.P., Blanc, G., Glowinski, J., 1976b. Topographical and pharmacological study of the mesocortical dopaminergic systems. In: Wauqnier, A., Rolls, E.T. (Eds.), Brain Stimulation Reward. North-Holland, Amsterdam, pp. 290–293.
  43. Tzschentke, 1997, Electrical stimulation of the medial prefrontal cortex elicits release of dopamine and glutamate in nucleus accumbens and ventral tegmental area in rats: effects of different frequencies and currents, Soc. Neurosci. Abstr., 23, 1753
  44. Tzschentke, T.M., Schmidt, W.J., 1998b. Functional heterogeneity of the medial prefrontal cortex and its relevance for drug reward. On-line Proceedings of the Fifth Internet World Congress on Biomedical Sciences (INABIS)’ 98 at McMaster University, Canada (available from URL: http://www.mcmaster.ca/inabis98/).
  45. Uylings, H.B.M., van Eden, C.G., De Bruin, J.P.C., Corner, M.A., Feenstra, M.G.P. (Eds.), 1990. The prefrontal cortex—its structure, function and pathology. Progress in Brain Research, vol. 85. Elsevier, Amsterdam.
  46. van Eden, 1997, Efferents from the rat medial prefrontal cortex can influence dopaminergic cells in the ventral tegmental area, which project to the nucleus accumbens, Soc. Neurosci. Abstr., 23, 1213
  47. Weiner, 1990, Disruption of latent inhibition by a low dose of amphetamine is antagonised by haloperidol and apomorphine, J. Psychopharmacol., 4, 255
  48. White, F.J., Wachtel, S.R., Johansen, P.A., Einhorn, L.C., 1987. Electrophysiological studies of the rat mesoaccumbens dopamine systems: focus on dopamine receptor subtypes, interactions, and the effect of cocaine. In: Chiodo, L.A., Freeman, F.A. (Eds.), Neurophysiology of dopaminergic systems: current status and clinical perspectives. Lakeshore, Detroit, pp. 317–365.
  49. White, F.J., Hu, X.T., Henry, D.J., Zhang, X.F., 1995a. Neurophysiological alterations in the mesocorticolimbic dopamine system with repeated cocaine administration. In: Hammer Jr, R.P. (Ed.), The Neurobiology of Cocaine: Cellular and Molecular Mechanisms. CRC Press, Boca Raton, FL, pp. 99–119.
  50. Yang, 1996, Focal dendritic D1 receptor stimulation differentially modulates layers I-II and V-VI glutamate inputs to deep layer prefrontal cortical pyramidal neurons in vitro, Soc. Neurosci. Abstr., 22, 1770

Cited by

Sorted by citations

See all 481

Related

Metadata

Authors
Tzschentke, T. M.
Affiliations
Grünenthal Group (Germany) (DE)
Corresponding author
Tzschentke, T.M.
ORCID
Tzschentke, T.M.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2001-02
Volume
63
Issue
3
Pages
241-320
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/s0301-0082(00)00033-2
OpenAlex
W2111304405
Semantic Scholar
314205aef63746557803f0214ed764321bbe28dc
Cited by
481
References
1,268
Citations by year
2026: 1 · 2025: 4 · 2024: 9 · 2023: 19 · 2022: 7 · 2021: 6 · 2020: 8 · 2019: 13 · 2018: 6 · 2017: 17 · 2016: 14 · 2015: 24 · 2014: 21 · 2013: 11 · 2012: 24
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
mesocortical dopamine system, prefrontal cortex, medial prefrontal cortex, glutamate, dopamine-glutamate interaction, mesocorticolimbic circuit, reward, addiction, locomotor activity, sensitization, learning, cognition, schizophrenia
MeSH terms
Animals, Behavior, Animal, Dopamine, Humans, Synaptic Transmission, Neurons, Prefrontal Cortex, Ventral Tegmental Area

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review