CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

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RU486 (MIFEPRISTONE): Mechanisms of Action and Clinical Uses

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The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

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The Nuclear Corepressors NCoR and SMRT Are Key Regulators of Both Ligand- and 8-Bromo-Cyclic AMP-Dependent Transcriptional Activity of the Human Progesterone Receptor

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The assay of progestin

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The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

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New steroids with antiprogestational and antiglucocorticoid activities

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Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP

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Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.

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Characterization and Functional Properties of the A and B Forms of Human Progesterone Receptors Synthesized in a Baculovirus System

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Modulation of cell signaling pathways can enhance or impair glucocorticoid-induced gene expression without altering the state of receptor phosphorylation.

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Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

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History and perspectives of antiprogestins from the chemist's point of view

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Antiprogestins: Mechanism of Action and Contraceptive

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The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI 3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins

Wagner, B. L., Pollio, G., Giangrande, P. H., Webster, J. C., Breslin, M. B., Mais, D. E., Cook, C. E., Vedeckis, W. V., Cidlowski, J. A., & McDonnell, D. P. (1999) · Endocrinology · doi:10.1210/endo.140.3.6581 · Cited by 71

EFFECT OF LOCAL APPLICATION OF PROGESTERONE ON THE RABBIT UTERUS

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Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium

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Progesterone receptor modulators and progesterone antagonists in women's health

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New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties.

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CDB-2914: Anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits

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Estrogenic and progestagenic activities coexisting in steroidal drugs: Quantitative evaluation by In vitro bioassays with human cells

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Human progesterone receptor A and B isoforms in CHO cells. II. Comparison of binding, transactivation and ed50 values of several synthetic (anti)progestagens in vitro in CHO and MCF-7 cells and in vivo in rabbits and rats

Schoonen, W. G. E. J., Dijkema, R., de Ries, R. J. H., Wagenaars, J. L., Joosten, J. W. H., de Gooyer, M. E., Deckers, G. H., & Kloosterboer, H. J. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00161-1 · Cited by 41

Antiovulatory and postcoital antifertility activity of the antiprogestin CDB-2914 when administered as single, multiple, or continuous doses to rats

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RU486

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Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids

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Antagonist effect of RU 486 on transcription of glucocorticoid-regulated genes

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Biological potencies of chemically modified adrenocorticosteroids in rat and man

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Activation of pRL-TK by 12S E1A Oncoprotein: Drawbacks of Using an Internal Reference Reporter in Transcription Assays

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Transcriptional regulation of the glycoprotein hormone α-subunit gene by pituitary adenylate cyclase-activating polypeptide (PACAP) in αT3-1 cells1This work was presented in part at the 10th International Congress of Endocrinology, 1996.1

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Ulipristal Acetate versus Placebo for Fibroid Treatment before Surgery

Donnez, J., Татарчук, Т. Ф., Bouchard, P., Pușcașiu, L., Zakharenko, N. F., Ivanova, T. V., Ugocsai, G., Mára, M., Jilla, M. P., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103182 · Cited by 679

Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids

Donnez, J., Tomaszewski, J., Vázquez, F., Bouchard, P., Lemieszczuk, B., Baró, F., Nouri, K., Selvaggi, L. E., Sodowski, K., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103180 · Cited by 604

Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications

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Progesterone Receptor Modulator for Emergency Contraception

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Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility

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In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone

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CDB-2914: Anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits

Hild, S. A. (2000) · Human Reproduction · doi:10.1093/humrep/15.4.822 · Cited by 46

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Binding affinity of mifepriston to progesterone and glucocorticoid receptors

Ya-l, B. (2005) · Shandong yiyao

New analogues of mifepristone with more dissociated antiprogesterone activities

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