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Cited by 145Ion channel regulation and functionProstate Cancer Treatment and ResearchIon Transport and Channel Regulation

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Expression and activity of potassium ion channels in human prostate cancer

Abdul, Mansoor, Hoosein, Naseema·2002·Cancer Letters
DOI 10.1016/s0304-3835(02)00348-8
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Abstract

Four normal and 79 human prostate cancer (Pca) specimens were examined, by immunohistochemistry, for expression of voltage-gated potassium ion channels. Strong immunostaining (for Kv1.3) was observed in the normal and 47% (37/79) of Pca specimens. Twenty-nine percent (23/79) Pca specimens showed moderate and 24% (19/79) displayed low staining. Three potassium channel-openers at a concentration of 10 microg/mL, minoxidil (47.8 microM), 1-Ethyl-2-benzimidazolinone (EBIO) (61.7 microM) and diazoxide (43.3 microM), increased growth of PC3 cells by 30-50%. Potassium channel-blockers, dequalinium, amiodarone and glibenclamide, caused a dose-dependent, growth inhibition of four human Pca cell lines. Apoptosis occurred within 4h of treatment of PC3 cells with dequalinium (0.5 microg/mL, 0.9 microM), amiodarone (5 microg/mL, 7.3 microM) or glibenclamide (50 microg/mL, 0.1mM).

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  • Pharmacological or genetic block of Kv channels reduces proliferation of cancer cells.

    “Numerous studies have shown that pharmacological or genetic block of Kv channels reduces proliferation of cancer cells”

    From Membrane potential and cancer progression (2013) · cites this paper as Abdul and Hoosein, 2002

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Research works printed but not linked: 28

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Metadata

Authors
Abdul, M., & Hoosein, N.
Corresponding author
Hoosein, Naseema
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2002-12
Volume
186
Issue
1
Pages
99-105
ISSN
0304-3835 (ISSN-L)
DOI
10.1016/s0304-3835(02)00348-8
OpenAlex
W1999073594
Cited by
145
References
0
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 9 · 2012: 2
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA 63225)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
prostate cancer, voltage-gated potassium channels, Kv1.3 potassium channel, potassium channel openers, potassium channel blockers, minoxidil, diazoxide, dequalinium, amiodarone, glibenclamide, PC-3 cells, apoptosis, cell growth inhibition, ion channel expression
MeSH terms
Anti-Arrhythmia Agents, Diazoxide, Dose-Response Relationship, Drug, Humans, Immunohistochemistry, Male, Minoxidil, Prostatic Neoplasms, Potassium Channels, Apoptosis, Potassium Channels, Voltage-Gated, Potassium Channel Blockers, Kv1.3 Potassium Channel

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