Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum
Abstract
Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrobrevin in the adult rat cerebellum immunohistochemically. Confocal microscopy showed that dystrobrevin was expressed around blood vessels and under the pia mater as dystrophin, utrophin and beta-dystroglycan were. Immunoelectron microscopy demonstrated that dystrobrevin was localized not only in the astrocytic endfeet around blood vessels and under the pia mater, but also in endothelial cells. Considering the fact that dystrobrevin possesses multiple phosphotyrosine kinase residues, these data suggest that dystrobrevin plays a role in blood-brain barrier functions as a component of the dystrophin complex.
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The dystrophin complex operates as a scaffold protein to recruit actin and vinculin filaments, maintaining the endothelial cytoskeletal network.
“Additionally, dystrophin complex operates as a scaffold protein to recruit actin and vinculin filaments, which maintains the endothelial cytoskeletal network (603).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [603]
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Brain endothelial cells and the glio-vascular complex
Wolburg, H., Noell, S., Mack, A., Wolburg-Buchholz, K., & Fallier-Becker, P. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0658-9 · Cited by 438 · see citing works
Severe alterations of endothelial and glial cells in the blood‐brain barrier of dystrophic mdx mice
Nico, B., Frigeri, A., Nicchia, G. P., Corsi, P., Ribatti, D., Quondamatteo, F., Herken, R., Girolamo, F., Marzullo, A., Svelto, M., et al. (2003) · Glia · doi:10.1002/glia.10216 · Cited by 172 · see citing works
- Authors
- Ueda, H., Baba, T., Terada, N., Kato, Y., Fujii, Y., Takayama, I., Mei, X., & Ohno, S.
- Affiliations
- University of Yamanashi (JP)
- Corresponding author
- Ueda, Hideho
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 283
- Issue
- 2
- Pages
- 121-124
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2054209993
- Cited by
- 51
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- dystrobrevin, alpha-dystrobrevin, dystrophin complex, astrocytic endfeet, endothelial cells, cerebellum, blood-brain barrier, dystrophin, utrophin, beta-dystroglycan, subcellular localization
- MeSH terms
- Animals, Astrocytes, Cerebellum, Cerebrovascular Circulation, Cytoskeletal Proteins, Endothelium, Vascular, Immunohistochemistry, Male, Membrane Glycoproteins, Membrane Proteins, Pia Mater, Dystrophin, Microscopy, Immunoelectron, Rats, Sprague-Dawley, Microscopy, Confocal, Dystrophin-Associated Proteins, Dystroglycans, Utrophin, Rats
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