The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Apolipoprotein E in Southern Italy: protective effect of ε2 allele in early- and late-onset sporadic Alzheimer's disease
Abstract
Apolipoprotein E (apoE) polymorphism was evaluated in 81 sporadic late onset Alzheimer's disease (LOAD) patients, 28 sporadic early-onset Alzheimer's disease (EOAD) and 92 sex- and age-matched healthy controls from Apulia, Southern Italy. ApoE genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism method. The frequency of apoE epsilon 4 allele was significantly higher in EOAD patients than in the control group, but not in LOAD patients. Furthermore, EOAD patients carrying epsilon 4 allele had lower age at onset of AD symptoms (about 4. 5 years). In the whole sample, epsilon 4 was associated to AD by an odds ratio of 2.14, while it increased up to 6.55 in or = 65 subgroups of subjects, epsilon 2 played a protective role against the development of AD. It is concluded that the geographic decreasing trend of epsilon 4 allele and the age at onset may influence the association of apoE polymorphism with sporadic AD in a Southern Italian sample.
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ApoE2 is protective against Alzheimer's disease.
“By contrast and by comparison, ApoE2 is protective against AD (Corder et al., 1994; Panza et al., 2000; West et al., 1994).”
From NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load (2021) · cites this paper as Panza et al., 2000
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Cites
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
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Research works printed but not linked: 19
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NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load
Pohlkamp, T., Xian, X., Wong, C. H., Durakoglugil, M. S., Werthmann, G. C., Saido, T. C., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · eLife · doi:10.7554/elife.72034 · Cited by 46
Metadata
- Authors
- Panza, F., Solfrizzi, V., Torres, F., Mastroianni, F., Colacicco, A. M., Basile, A. M., Capurso, C., D'Introno, A., Del Parigi, A., & Capurso, A.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 292
- Issue
- 2
- Pages
- 79-82
- ISSN
- 0304-3940
- Cited by
- 33
- References
- 1
- Language
- en
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