Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat
Abstract
This study tested the effect of exposure to bisphenol A (BPA) early in life on the sexual differentiation in the brain and behavior in Wistar rats. We administered BPA only to mother rats during pregnancy and lactation at a dosage of approximately 1.5 mg/kg per day far less than the no-observed-adverse-effect level (NOAEL; 50 mg/kg per day). Control female offspring showed a higher activity, a lower avoidance memory, and larger locus coeruleus than the male controls, while the BPA-exposed group did not show any sexual dimorphism. BPA did not affect the reproductive organs or sex hormones. Our results suggest that the current methods to determine the NOAEL of artificial industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain.
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BPA has been demonstrated to be associated with alteration in sexual dimorphisms of the CNS and behavioral impairment in rats.
“BPA has been demonstrated to be associated with alteration in sexual dimorphisms of the central nervous system (CNS) and behavioral impairment in rats1.”
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209 · see citing works
Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.02.012 · Cited by 211 · see citing works
Kajta, M., & Wójtowicz, A. K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71524-x · Cited by 168 · see citing works
Liu, Z.-H., Ding, J.-J., Yang, Q.-Q., Song, H.-Z., Chen, X.-T., Xu, Y., Xiao, G.-R., & Wang, H.-L. (2016) · Scientific Reports · doi:10.1038/srep32492 · Cited by 53 · see citing works
“910, respectively) or main factor of sex (F(1, 35) = 0.”
Background
- Authors
- Kubo, K., Arai, O., Ogata, R., Omura, M., Hori, T., & Aou, S.
- Affiliations
- Kyushu University (JP)
- Dokkyo University (JP)
- Corresponding author
- Aou, Shuji
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 304
- Issue
- 1-2
- Pages
- 73-76
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2007350333
- Cited by
- 150
- References
- 0
- Citations by year
- 2023: 1 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 11 · 2013: 11 · 2012: 5
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- bisphenol A, endocrine disruptors, sexual differentiation of the brain, locus coeruleus, prenatal exposure, suckling period, maternal exposure, sexual dimorphism, avoidance memory, behavior, no-observed-adverse-effect level, developmental neurotoxicity
- MeSH terms
- Bisphenol A Compounds, Animals, Avoidance Learning, Benzhydryl Compounds, Estrogens, Non-Steroidal, Female, Locus Coeruleus, Male, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Sexual Behavior, Animal, Sex Differentiation, Rats, Wistar, Rats
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