SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice
Open accessAbstract
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.
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A modified SHIRPA screen was used to analyze the general health of each animal pre- and post-infection, as previously described.
“A modified SHIRPA screen was used to analyze the general health of each animal pre- and post-infection (Rogers et al., 1997).”
From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Rogers et al., 2001
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References 5 · Cited by 199
- Authors
- Rogers, D. C., Peters, J., Martin, J. E., Ball, S., Nicholson, S. J., Witherden, A. S., Hafezparast, M., Latcham, J., Robinson, T. L., Quilter, C. A., & Fisher, E. M. C.
- Affiliations
- GlaxoSmithKline (United Kingdom) (GB)
- Queen Mary University of London (GB)
- Imperial College London (GB)
- Corresponding author
- Rogers, Derek C.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 306
- Issue
- 1-2
- Pages
- 89-92
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2063848772
- Cited by
- 199
- References
- 5
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- behavioral phenotyping, neurological disorders, longitudinal assessment, mouse mutants
- MeSH terms
- Animals, Behavior, Animal, Body Weight, Central Nervous System Diseases, Disease Models, Animal, Female, Genotype, Longitudinal Studies, Male, Mice, Neurologic Mutants, Movement, Phenotype, Physical Examination, Posture, Psychomotor Performance, Sex Characteristics, Reproducibility of Results, Gait Disorders, Neurologic, Mice
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