Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome.
Abstract
Ts65Dn mouse displays a partial triplication of chromosome 16 and is adopted as a model for Down syndrome (DS). It is known that Ts65Dn mice present memory deficiencies. In order to gain insight into the cause of these deficiencies, we studied the possibility of changes in volumes and neuronal numbers in different regions of the hippocampus (dentate gyrus, CA3, CA2 and CA1) in trisomic mice as compared to control littermates using stereological methods. The mean hippocampal volumes of Ts65Dn mice did not show significant differences as compared to controls, except in CA2 where there was a barely significant decrease. However, mean neuron number was significantly lower in Ts65Dn mice than in controls in dentate gyrus (43.7 x 10(4), CV 21%, n = 5, vs. 30.4 x 10(4), CV 18.1%, n = 4) and higher in CA3 (23.1 x 10(4), CV 18.9% vs. 33.3 x 10(4), CV 14.9%). These quantitative changes may account for the memory deficiencies observed in Ts65Dn mice.
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Similar to human studies, neuronal hypocellularity has been detected in multiple structures including the cortex, cerebellum, and hippocampus in postnatal trisomic Ts65Dn animals.
“Similar to human studies, neuronal hypocellularity has been detected in multiple structures including the cortex, cerebellum, and hippocampus in postnatal trisomic animals (Insausti et al., 1998; Baxter et al., 2000; Olson et al., 2004; Roper et al., 2006; Chakrabarti et al., 2010; Aziz et al., 2018).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Insausti et al., 1998
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References 18 · Cited by 149
- Authors
- Insausti, A. M., Megı́as, M., Crespo, D., Cruz-Orive, L. M., Dierssen, M., Vallina, T. F., Insausti, R., & Flórez, J.
- Affiliations
- Universidad de Cantabria (ES)
- Universidad de Navarra (ES)
- Corresponding author
- Insausti, R.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 253
- Issue
- 3
- Pages
- 175-178
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2088404776
- Cited by
- 149
- References
- 18
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 10
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Ts65Dn mouse model, Down syndrome, trisomy 16, hippocampus, neuron number, hippocampal volume, dentate gyrus, CA3, CA2, CA1, memory impairment, stereology
- MeSH terms
- Animals, Cell Count, Disease Models, Animal, Down Syndrome, Hippocampus, Immunohistochemistry, Mice, Neurologic Mutants, Trisomy, Dentate Gyrus, Mice
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