Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony
Abstract
Circadian timing was assessed with forced desynchrony (FD) in 10 healthy adolescents (five boys, five girls; mean age 13.7 years). Following 10 days of entrainment to a fixed light-dark (LD) schedule at home, participants were studied under dim light (<20 lux) in the laboratory. A 28-h schedule (FD) was imposed for 12 x 28-h cycles. Saliva was collected at 30- or 60-min intervals throughout; core temperature was measured in constant routines (CR) before and after FD. Intrinsic circadian period was estimated by linear regression using temperature minimum from CRs and dim-light salivary melatonin onsets and offsets from FD. Average intrinsic circadian period for core temperature (n = 7) was 24.30+/-0.20, for melatonin onset was 24.33+/-0.21, and for melatonin offset was 24.35+/-0.21. Intrinsic circadian period in every adolescent was greater than 24 h.
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Human adolescents have an endogenous period of 24.27 h, significantly longer than the period length found in adults (24.12 h) using similar protocols.
“They found that human adolescents have an endogenous period of 24.27 h, significantly longer than the period length found in adults (24.12 h) using similar protocols [28, 34].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [34]
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References 15 · Cited by 173
- Authors
- Carskadon, M. A., Labyak, S. E., Acebo, C., & Seifer, R.
- Affiliations
- Brown University (US)
- Corresponding author
- Carskadon, Mary A
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 260
- Issue
- 2
- Pages
- 129-132
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1971807107
- Cited by
- 173
- References
- 15
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 2 · 2013: 9 · 2012: 4
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001358-03)
- National Institute of Mental Health (MH52415, MH01358, R01MH052415)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- forced desynchrony, adolescents, circadian timing, core body temperature, dim light melatonin onset, constant routine, light-dark cycle entrainment, sleep-wake cycle
- MeSH terms
- Adolescent, Body Temperature, Child, Circadian Rhythm, Female, Humans, Light, Male, Melatonin, Saliva
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