Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells
Abstract
Inflammatory cells and their mediators are known to contribute to neuropathic pain following nerve injury. Mast cells play a key role in non-neural models of inflammation and we propose that mast cells and their mediators (in particular histamine) are important in the development of neuropathic pain. In rats, where the sciatic nerve was partially ligated, we showed that stabilisation of mast cells with sodium cromoglycate reduced the recruitment of neutrophils and monocytes to the injured nerve and suppressed the development of hyperalgesia. Treatment with histamine receptor antagonists suppressed the development of hyperalgesia following nerve injury and alleviated hyperalgesia once it was established. These results suggest that mast cell mediators such as histamine released within hours of nerve injury contribute to the recruitment of leukocytes and the development of hyperalgesia.
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Treatment with histamine receptor antagonists suppressed the development of hyperalgesia after nerve injury and alleviated hyperalgesia once it was established.
“Treatment with histamine receptor antagonists also suppressed the development of hyperalgesia after nerve injury and alleviated hyperalgesia once it was established (45).”
From Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis (2006) · cites this paper as [45]
In animal models, stabilization of mast cells by sodium cromoglycate suppressed the development of hyperalgesia.
“Indeed, it has been demonstrated in animal models that the stabilization of mast cells by sodium cromoglycate suppressed the development of hyperalgesia.”
From Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis (2006) · cites this paper as [45]
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References 71 · Cited by 221
- Authors
- Zuo, Y., Perkins, N. M., Tracey, D. J., & Geczy, C. L.
- Affiliations
- UNSW Sydney (AU)
- Venue
- Pain
- Published
- 2003-10
- Volume
- 105
- Issue
- 3
- Pages
- 467-479
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2034949619
- Cited by
- 221
- References
- 71
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 16 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 19 · 2012: 17
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University of New South Wales
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- mast cells, neuropathic pain, hyperalgesia, nerve injury, sciatic nerve ligation, histamine, disodium cromoglycate, antihistamines, neutrophil recruitment, monocyte recruitment, inflammatory mediators, leukocyte recruitment
- MeSH terms
- Animals, Hyperalgesia, Inflammation, Male, Mast Cells, Rats, Wistar, Sciatic Neuropathy, Rats
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