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Cited by 30Cellular transport and secretionSlime Mold and Myxomycetes ResearchAutophagy in Disease and Therapy

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Dictyostelium discoideum: a genetic model system for the study of professional phagocytes

Janssen, Klaus-Peter, Schleicher, Michael·2001·Biochimica et Biophysica Acta (BBA) - General Subjects
DOI 10.1016/s0304-4165(01)00108-8
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Abstract

Profilin is a key regulator of actin polymerization, and plays a pivotal role at the interface of the phosphoinositide signal transduction pathway and the cytoskeleton. Recent evidence suggests the involvement of profilin in the regulation of phagocytosis and macropinocytosis, and the transport along the endosomal pathway. Disruption of profilin leads to a complex phenotype that includes abnormal cytokinesis, a block in development and defects in the endosomal pathway. Macropinocytosis, fluid phase efflux and secretion of lysosomal enzymes were reduced, whereas the rate of phagocytosis was increased as compared to wild-type cells. The lmpA gene, a homolog of the CD36/LIMPII family, was identified as a suppressor for most of the profilin-minus defects. This gene encodes an integral membrane protein, it localizes to lysosomes and macropinosomes, and binds to phosphoinositides. Even though phosphatidylinositol lipids constitute only a small fraction of total lipids in the membranes of eukaryotic cells, they play an important role in vesicle transport, signal transduction and cytoskeletal regulation. Disruption of lmpA in wild-type cells resulted in defects in fluid phase efflux and macropinocytosis, but not in phagocytosis. The discovery and initial characterization of two additional members of the CD36/LIMPII family in Dictyostelium, lmpB and lmpC, that exhibit intriguing differences in developmental regulation and their putative sorting signals, suggests that a set of lysosomal integral membrane proteins contribute to the crosstalk between vesicles and cytoskeletal proteins.

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Metadata

Authors
Janssen, K.-P., & Schleicher, M.
Affiliations
Adolf-Butenandt-Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie (DE)
Corresponding author
Schleicher, Michael
ORCID
Janssen, Klaus-Peter
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2001-03
Volume
1525
Issue
3
Pages
228-233
ISSN
0304-4165 (ISSN-L)
DOI
10.1016/s0304-4165(01)00108-8
OpenAlex
W39912051
Cited by
30
References
65
Citations by year
2017: 2 · 2016: 1 · 2013: 2 · 2012: 1
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Slime Mold and Myxomycetes Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords
Dictyostelium discoideum, profilin, phagocytosis, macropinocytosis, phosphoinositides, endocytic pathway, actin polymerization, cytokinesis, vesicle trafficking, professional phagocytes
MeSH terms
Animals, Contractile Proteins, Dictyostelium, Microfilament Proteins, Models, Genetic, Phagocytes, Phosphatidylinositols, Phylogeny, Receptors, Immunologic, Signal Transduction, Genes, Protozoan, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Profilins

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