The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer?
Abstract
It is proposed that bile acids (deoxycholic acid), the K vitamins, iron(II) complexes and oxygen interact to induce an oncogenic effect in the colon by the generation of free radicals. In the relatively low oxidising/reducing conditions of the colonic lumen the K vitamins exist in the reduced form; however, if absorbed into the mucosa they have the capacity to be chemically oxidised and to enter into a redox cycle yielding oxygen radicals. The semiquinone radical of K(1) (phylloquinone) has been stabilised in bile acid mixed micelles and investigated by electron paramagnetic resonance spectroscopy and quantum chemical calculations. The estimated half-life of the radical was about 30 min which confirms a remarkably high stability in aqueous micellar solution. A model is presented in which the reduced K vitamins may initiate superoxide radical, O2(-*) generation leading to Fe(II) mediated Fenton reactions in the stem colon cells.
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“Red meat contains high content of iron which may catalyze ROS formation in the colon in the process of digestion (Valko et al. 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Valko et al. 2001
In the citing paper
“A positive correlation between the high consumption of red meat and the incidence of colon cancer has been proposed (Valko et al. 2001).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Valko et al. 2001
Citations
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Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Self-citationFree radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Self-citationAdvances in metal-induced oxidative stress and human disease
Jomová, K., & Valko, M. (2011) · Toxicology · doi:10.1016/j.tox.2011.03.001 · Cited by 3,291
Self-citationReactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Self-citationRole of oxygen radicals in DNA damage and cancer incidence
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820
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Metadata
- Authors
- Valko, M., Morris, H., Mazúr, M., Rapta, P., & Bilton, R. F.
- Affiliations
- Slovak University of Technology in Bratislava (SK)
- Liverpool John Moores University (GB)
- Corresponding author
- Valko, Marián
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 1527
- Issue
- 3
- Pages
- 161-166
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2006276599
- Cited by
- 124
- References
- 30
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education and Science (1/733/93)
- North West Cancer Research
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Keywords
- oxygen free radicals, colon cancer, vitamin K, vitamin K1, semiquinone, bile acids, deoxycholic acid, iron(II) complexes, Fenton reaction, superoxide, redox cycling, colonic mucosa, radical stability, mixed micelles
- MeSH terms
- Bile Acids and Salts, Colon, Colonic Neoplasms, Diet, Electron Spin Resonance Spectroscopy, Half-Life, Humans, Intestinal Mucosa, Micelles, Models, Chemical, Oxidation-Reduction, Vitamin K 1, Quinones, Superoxides, Vitamin K, Molecular Structure
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