Contributions of Myc to tumorigenesis
Abstract
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes to tumorigenesis are still not fully resolved and many aspects are still enigmatic. Several recent reviews, including one published in this series a few months ago, have summarized recent progress in our understanding of the biochemistry of Myc proteins [Eisenmann, Genes Dev. (2001) in press; Amati et al., Biochim. Biophys. Acta 1471 (2001) 135-145]. Also, the evidence documenting a central role of Myc proteins in human tumorigenesis has been extensively reviewed [Henriksson and Lüscher, Cancer Res. 68 (1996) 109-182]. In this article, we will argue that current progress allows us to present testable hypotheses on how Myc affects specific properties of transformed cells.
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G4s have been predominantly associated with the promoters of oncogenes such as MYC, KIT or KRAS, where their stabilization is associated with suppressed oncogene expression.
“While G4s have been predominantly associated with the promoters of oncogenes such as MYC, KIT or KRAS (23–25), where their stabilization is associated with suppressed oncogene expression”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [24]
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The c‐myc Promoter: Still MysterY and Challenge
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G-quadruplex-mediated genomic instability drives SNVs in cancer
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- Authors
- Lutz, W., Leon, J., & Eilers, M.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Eilers, Martin
- ORCID
- Eilers, Martin
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 1602
- Issue
- 1
- Pages
- 61-71
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W2048743409
- Cited by
- 177
- References
- 9
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 2 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 8 · 2013: 8 · 2012: 6
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Keywords
- Myc proteins, carcinogenesis, oncogene deregulation, transformed cells, malignant transformation
- MeSH terms
- Animals, Cell Division, Cell Line, DNA-Binding Proteins, Humans, Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc, Genome, Cellular Senescence, Cell Cycle Proteins, Cyclin E, E2F Transcription Factors
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