Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running
Abstract
Voluntary wheel running in rats increases hippocampal brain-derived neurotrophic factor (BDNF) expression, a neurochemical important for neuronal survival, differentiation, connectivity and synaptic plasticity. Here, we report the effects of wheel running on BDNF and neurotrophin-3 (NT-3) protein levels in normal control mice, and in mice selectively bred (25 generations) for increased voluntary wheel running. We hypothesized that increased voluntary wheel running in selected (S) mice would increase CNS BDNF and NT-3 protein levels more than in control (C) mice. Baseline hippocampal BDNF levels (mice housed without running wheels) were similar in S and C mice. Following seven nights of running, hippocampal BDNF increased significantly more in S versus C mice, and levels were correlated with distance run (considering C and S mice together). Spinal and cerebellar BDNF and hippocampal NT-3 levels were not significantly affected by wheel running in any group, but there was a small, positive correlation between spinal C3-C6 BDNF levels and distance run (considering C and S mice together). This is the first study to demonstrate that mice which choose to run more have greater elevations in hippocampal BDNF, suggesting enhanced potential for exercise-induced hippocampal neuroplasticity.
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In mice that regularly exercised, the increase in BDNF levels following exercise was amplified relative to mice after just a single session.
“This effect, however, became amplified following a period of exercise in mice that regularly exercised, with an increased response in BDNF levels relative to mice after just a single session of exercise (Johnson et al., 2003; van Praag et al., 2005; Rasmussen et al., 2009).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Johnson et al., 2003
In mice, even one session of exercise increased BDNF levels.
“It was found that in mice, even just one session of exercise increased BDNF levels.”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Johnson et al., 2003
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References 50 · Cited by 113
- Authors
- Johnson, R. A., Rhodes, J. S., Jeffrey, S. L., Garland, T., & Mitchell, G. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Oregon Health & Science University (US)
- University of California, Riverside (US)
- Corresponding author
- Mitchell, G.S
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 121
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2011319923
- Cited by
- 113
- References
- 50
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL036780, HL 36780, HL03874)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- voluntary wheel running, brain-derived neurotrophic factor, neurotrophin-3, hippocampus, exercise-induced neuroplasticity, running distance, cerebellum, neurotrophins
- MeSH terms
- Animals, Breeding, Female, Hippocampus, Male, Mice, Inbred ICR, Motor Activity, Brain-Derived Neurotrophic Factor, Neurotrophin 3, Mice
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