Endotoxin-induced changes in sleep and sleepiness during the day
Abstract
Sleepiness is a common symptom of infectious diseases. However, the peculiarities and causes of impaired vigilance during host defense activation are largely unknown. It has been shown earlier that mild host defense activation by endotoxin does not affect daytime sleepiness and non-rapid eye movement (NREM) sleep in humans. In the present study we investigated the effects of a more intensive stimulation of the host defense by Salmonella abortus equi endotoxin (0.8 ng/kg), administered 12 h following host response priming by granulocyte colony-stimulating factor (300 micrograms s.c.), on daytime sleep and sleepiness in a placebo-controlled design in ten healthy men. Six equidistant polysomnographically monitored naps were scheduled across the day and the time course of subjective sleepiness was assessed. Endotoxin induced prominent increases in rectal temperature, and in the plasma levels of tumor necrosis factor-alpha, interleukin-6, interleukin-1 receptor antagonist, and cortisol. In the first nap, 1 h following endotoxin administration, total sleep time and NREM sleep stage 2 were reduced, whereas wakefulness and sleep onset latency were increased. Following this nap sleepiness transiently increased peaking prior to the second nap. However, this nap and the following ones were not influenced by endotoxin. These results suggest that prominent host defense activation reduces daytime NREM sleep and increases sleepiness. One cause of daytime sleepiness during infections may be…
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Very low doses of endotoxin (0.2 ng/kg) promoted sleep.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Hermann et al., 1998
Moderate doses of endotoxin (0.8 ng/kg) reduced total sleep time.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Hermann et al., 1998
Moderate doses of endotoxin (0.8 ng/kg) increased sleep onset latency.
“For example, very low doses of endotoxin (0.2 ng/kg) promoted sleep, whereas moderate doses (0.8 ng/kg) reduced total sleep time and increased sleep onset latency (Hermann et al., 1998; Korth et al., 1996; Mullington et al., 2000).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Hermann et al., 1998
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References 28 · Cited by 45
- Authors
- M. Hermann, D.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 23
- Issue
- 5
- Pages
- 427-437
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2171929381
- Cited by
- 45
- References
- 28
- Citations by year
- 2025: 2 · 2024: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- endotoxin, Salmonella abortus equi, daytime sleepiness, daytime sleep, NREM sleep, sleep disruption, TNF-α, interleukin-6, interleukin-1 receptor antagonist, cortisol, granulocyte colony-stimulating factor, sleep latency, sleep pressure, infection
- MeSH terms
- Adult, Arousal, Bacterial Toxins, Blood Cell Count, Body Temperature, Endotoxins, Humans, Hydrocortisone, Interleukin-1, Male, Salmonella, Sleep, Sleep Stages, Tumor Necrosis Factor-alpha, Interleukin-6, Polysomnography
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