Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis
Abstract
Currently the etiology of osteoporosis is attributed to various endocrine, metabolic, and mechanical factors. We hypothesize that many cases of osteoporosis are also partially attributable to a maladaptation of the link between inflammation and bone turnover. We explore the spatial and temporal link between inflammation and osteoporosis in conditions such as aging, menopause, reflex sympathetic dystrophy, HIV, pregnancy, transplantation, and steroid administration. While nutritional and mechanical factors clearly play a role in many of these situations, the spatial and temporal concordance of osteoporosis and inflammation is buttressed by emerging molecular evidence. Modern bone biology of humans may reflect dual functional legacies of mineral storage and structural support. Osteoporosis may result from disequilibrium between structural demand for key minerals and their biologic demand during maladaptive states of inflammation.
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Chronically elevated inflammation processes are linked to increased risks for osteoporosis, cardiovascular disease, and cognitive decline.
“Exposure to chronically elevated inflammation processes has also been increasingly recognized as a significant health risk with links to increased risks for osteoporosis, 38,39 cardiovascular disease, [40][41][42][43][44][45] and cognitive decline.[46][47][48]”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [38]
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References 60 · Cited by 76
- Authors
- Yun, A. J., & Lee, P. Y.
- Affiliations
- Stanford University (US)
- Corresponding author
- Yun, A.Joon
- ORCID
- Yun, A.Joon
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 63
- Issue
- 3
- Pages
- 532-537
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2108112157
- Cited by
- 76
- References
- 60
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- osteoporosis, inflammation, bone turnover, maladaptation, aging, menopause, complex regional pain syndrome, HIV, pregnancy, transplantation, corticosteroids, bone biology, mineral storage
- MeSH terms
- Clinical Trials as Topic, Humans, Models, Biological, Osteitis, Osteoporosis, Cytokines, Bone Remodeling, Evidence-Based Medicine
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