Lesion of the bed nucleus of the stria terminalis enhances learned despair
Abstract
The bed nucleus of the stria terminalis (BNST) was lesioned in adult male Wistar rats (n = 9) and its involvement in coping behavior during forced swim stress examined. Rats remain immobile longer in the second of two swim tests, a phenomenon known as learned despair. Results revealed that, compared to sham-operated controls (n = 8), BNST-lesioned animals displayed immobility significantly earlier and for longer durations in the second swim test. Rats with BNST lesions also showed significantly reduced escape behavior in the form of fewer numbers of jumps and dives compared to controls. Mobility deficits were not due to general motor impairment as revealed by an open field test. Results suggest that the BNST may modulate coping behavior especially during uncontrollable stress.
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Lesions of the BNST alter despair behavior.
“Lesions of this nucleus alter despair behavior [92] and block the behavioral consequences of stress [93].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [92]
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References 44 · Cited by 57
- Authors
- Schulz, D., & Canbeyli, R. S.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Boğaziçi University (TR)
- Corresponding author
- Canbeyli, Resit S
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 52
- Issue
- 2
- Pages
- 83-87
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2044399304
- Cited by
- 57
- References
- 44
- Citations by year
- 2024: 2 · 2023: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2014: 1 · 2013: 7 · 2012: 1
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- bed nucleus of the stria terminalis, learned helplessness, despair, forced swim test, immobility, coping styles, uncontrollable stress, escape behavior, brain lesions, rats
- MeSH terms
- Adaptation, Psychological, Analysis of Variance, Animals, Escape Reaction, Helplessness, Learned, Male, Motor Activity, Reaction Time, Septal Nuclei, Stress, Psychological, Swimming, Rats, Wistar, Rats
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