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Cited by 66Olfactory and Sensory Function StudiesBiochemical Analysis and Sensing TechniquesReceptor Mechanisms and Signaling

The DOI matches its Crossref record.

Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species

Yuan, Thomas Ta-Tung, Toy, Pamela, McClary, John A., Lin, Richard J., Miyamoto, Neil G., Kretschmer, Peter J.·2001·Gene
DOI 10.1016/s0378-1119(01)00709-0
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Abstract

We have cloned the full-length cDNA and genomic region of a human prostate specific G-protein coupled receptor with properties characteristic of an olfactory receptor. A partial cDNA sequence of this gene, called PSGR, was recently cloned. The gene contains two exons and one intron of 14.9 kb in its 5'untranslated region, and was mapped to human chromosome 11p15.2. A cluster of transcription initiation sites for the 2.8 kb PSGR mRNA was identified. Cloning of the homologous gene from the mouse revealed 93% amino acid homology between the human and mouse or rat (previously cloned as RA1c) proteins, and 99% identity between the rat and mouse homologs. Although northern analysis indicated expression of the human PSGR homolog was prostate specific, its mRNA could also be detected in the olfactory zone and the medulla oblongata of the human brain. In the mouse, the PSGR gene is predominantly expressed in the brain and colon. In the rat, the PSGR homolog is expressed in the liver in addition to the brain. These data add to the growing body of evidence suggesting that olfactory receptors may have functional roles in tissues other than the olfactory organ, and further, suggest that these functions may vary across species.

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Research works printed but not linked: 19

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Metadata

Authors
Yuan, T. T.-T., Toy, P., McClary, J. A., Lin, R. J., Miyamoto, N. G., & Kretschmer, P. J.
Corresponding author
Kretschmer, Peter J.
ORCID
Lin, Richard J.
Venue
Gene
Publisher
Elsevier BV
Published
2001-10
Volume
278
Issue
1-2
Pages
41-51
ISSN
0378-1119 (ISSN-L)
DOI
10.1016/s0378-1119(01)00709-0
OpenAlex
W2052130505
Cited by
66
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
olfactory receptors, cDNA cloning, genome mapping, transcription start sites, species-specific expression, medulla oblongata, olfactory epithelium, colon, liver
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 11, Cloning, Molecular, DNA, Gene Expression Regulation, Humans, Male, Molecular Sequence Data, Neoplasm Proteins, RNA, Species Specificity, Tissue Distribution, Blotting, Northern, Sequence Alignment, Conserved Sequence, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Receptors, Odorant, DNA, Complementary, Evolution, Molecular, Transcription Initiation Site, 5' Flanking Region, Mice, Rats

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