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Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1).

Böttner, Martina, Laaff, Martin, Schechinger, Birgit, Rappold, Gudrun, Unsicker, Klaus, Suter-Crazzolara, Clemens·1999·Gene
DOI 10.1016/s0378-1119(99)00309-1
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Abstract

We have isolated the rat, mouse and human genes of a distant member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1) by screening of genomic libraries. All three genes are composed of two exons, and contain one single intron that interrupts the coding sequences at identical positions within the prepro-domain of the corresponding proteins. The predicted proteins contain the structural hallmarks of members of the TGF-beta superfamily, including the seven conserved carboxy-terminal cysteine residues that form the cystine knot. The orthologous molecules show the lowest sequence conservation of all members of the TGF-beta superfamily. RT-PCR reveals an abundant expression of GDF-15/MIC-1 mRNA in numerous embryonic and adult organs and tissues. Promoter analysis of the rat promoter indicates the presence of multiple regulatory elements, including a TATA-like sequence as well as several SP1, AP-1 and AP-2 sites. Deletion analysis suggests that a 350 bp region upstream of the start of the open reading frame appears to be the most important for regulation of transcription.

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Research works printed but not linked: 19

  1. Bootcov, 1997, MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily, Proc. Natl. Acad. Sci. USA, 94, 11514, 10.1073/pnas.94.21.11514 · DOI
  2. Böttner, 1999, Expression of a novel member of the TGF-β superfamily, growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues, Cell Tissue Res., 297, 103, 10.1007/s004410051337 · DOI
  3. Daopin, 1992, Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily, Science, 257, 369, 10.1126/science.1631557 · DOI
  4. Devereux, 1984, A comprehensive set of sequence analysis programs for the VAX, Nucleic Acids Res., 12, 387, 10.1093/nar/12.1Part1.387 · DOI
  5. Feng, 1989, Analysis of the 5′ flanking regions of rat inhibin α- and β-B-subunit genes suggests two different regulatory mechanisms, Mol. Endocrinol., 3, 1914, 10.1210/mend-3-12-1914 · DOI
  6. Florkiewicz, 1989, Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons, Proc. Natl. Acad. Sci. USA, 86, 3978, 10.1073/pnas.86.11.3978 · DOI
  7. Gitelman, 1997, Structure and sequence of the mouse Bmp6 gene, Mammalian Genome, 8, 212, 10.1007/s003359900391 · DOI
  8. Hogan, 1996, Bone morphogenetic proteins in development, Curr. Opin. Genet. Dev., 6, 432, 10.1016/S0959-437X(96)80064-5 · DOI
  9. Incerti, 1994, Structure of the mouse growth/differentiation factor 9 gene, Biochim. Biophys. Acta, 1222, 125, 10.1016/0167-4889(94)90034-5 · DOI
  10. Ishii, 1985, Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene, Proc. Natl. Acad. Sci. U. S. A., 82, 4902, 10.1073/pnas.82.15.4920 · DOI
  11. Kim, 1989, Characterization of the promoter region of the human transforming growth factor-beta 1 gene, J. Biol. Chem., 264, 402, 10.1016/S0021-9258(17)31272-3 · DOI
  12. Lafyatis, 1990, Structural and functional characterization of the transforming growth factor β3 promoter, J. Biol. Chem., 265, 19128, 10.1016/S0021-9258(17)30634-8 · DOI
  13. Kingsley, 1994, The TGF-beta superfamily: new members, new receptors and new genetic tests of function in different organisms, Genes Dev., 8, 133, 10.1101/gad.8.2.133 · DOI
  14. Massague, 1990, The transforming growth factor-β family, Annu. Rev. Cell Biol., 6, 597, 10.1146/annurev.cb.06.110190.003121 · DOI
  15. Malipiero, 1990, Sequence analysis of the promoter region of the glioblastoma derived T cell suppressor factor/transforming growth factor (TGF)-beta 2 gene reveals striking differences to the TGF-beta 1 and -beta 3 genes, Biochem. Biophys. Res. Commun., 171, 1145, 10.1016/0006-291X(90)90804-V · DOI
  16. Roberts, 1990, The transforming growth factor-βs, 419, 10.1007/978-3-642-49295-2_8 · DOI
  17. Seghal, 1988, A constitutive promoter directs expression of the nerve growth factor receptor gene, Mol. Cell. Biol., 8, 3160, 10.1128/MCB.8.8.3160 · DOI
  18. Wahl, 1992, Transforming growth factor beta (TGF-β) in inflammation: a cause and a cure, J. Clin. Immunol., 12, 66, 10.1007/BF00918135 · DOI
  19. Wozney, 1988, Novel regulators of bone formation: molecular clones and activities, Science, 242, 1428, 10.1126/science.3201241 · DOI

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Metadata

Authors
Böttner, M., Laaff, M., Schechinger, B., Rappold, G., Unsicker, K., & Suter-Crazzolara, C.
Venue
Gene
Publisher
Elsevier BV
Published
1999-09
Volume
237
Issue
1
Pages
105-111
ISSN
0378-1119
DOI
10.1016/s0378-1119(99)00309-1
Cited by
144
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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