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Cited by 5Photoreceptor and optogenetics researchLipid Membrane Structure and BehaviorReceptor Mechanisms and Signaling

The uncoupling of bacteriorhodopsin by high temperature and anaesthetics

Gao, Méi Méi, Boucher, François·1998·Toxicology Letters
DOI 10.1016/s0378-4274(98)00212-4
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Abstract

1. General anaesthetics induce reversible structural and functional modifications of the proton pump bacteriorhodopsin contained in the purple membrane of halobacteria. 2. This short paper describes the phenomenological similarity between the effects of anaesthetics and heating on this system. 3. pH dependence and thermal analysis suggest that the structural change taking place at room temperature in the presence of anaesthetic is the same as that observed at temperatures higher than 70 degrees C in the native membrane. In addition, part of the structural modification has an irreversible character when induced by anaesthetic as well as by heating.

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  • Volatile anesthetics act on species across the evolutionary tree, not only on human patients.

    “However, volatile anesthetics exert actions not only on human patients, but on species spanning the evolutionary tree of life [1–8] (Figure 1).”

    From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [4]

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References 13 · Cited by 5

Authors
Gao, M. M., & Boucher, F.
Affiliations
Université du Québec à Trois-Rivières (CA)
Corresponding author
Gao, Méi Méi
Venue
Toxicology Letters
Publisher
Elsevier BV
Published
1998-11
Volume
100-101
Pages
393-396
ISSN
0378-4274 (ISSN-L)
DOI
10.1016/s0378-4274(98)00212-4
OpenAlex
W2051455708
Cited by
5
References
13
Citations by year
2019: 1 · 2013: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Toxicology Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
bacteriorhodopsin, general anesthetics, high temperature, purple membrane, halobacteria, proton pump, protein conformational change, pH dependence, thermal analysis
MeSH terms
Anesthetics, Bacteriorhodopsins, Calorimetry, Differential Scanning, Hot Temperature, Hydrogen-Ion Concentration, Photochemistry, Spectrophotometry, Infrared, Temperature, Xenobiotics

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