The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The effects of antiepileptic drugs on spatial learning and hippocampal protein kinase C γ in immature rats
Abstract
This study was conducted to determine if alterations in hippocampal protein kinase C (PKC) gamma is one of the cellular mechanisms by which conventional antiepileptic drugs affect learning and memory. Wistar Rats (21-day-old) were divided into five groups: (1) control (no training and drugs); (2) training group (no drugs); (3) phenobarbital (PB) group; (4) carbamazepine (CBZ) group; and (5) valproate (VPA) group. A hippocampus dependent learning task (spatial changing learning) was used in the latter four groups lasting a total of 10 days. Correct responding rate of training group was significantly higher (P < 0.05) than in the PB, CBZ and VPA group. The PKC gamma staining intensity in hippocampal CA1-2 region of training group was significant greater than that of the control and PB group. There was no difference in staining intensities between the CBZ, VPA group or training group. The amount of PKC gamma located in plasma membrane of hippocampal neurons was significantly higher in the training group (P < 0.05) than the control, PB and VPA groups. No differences were found between the training and CBZ group. Lastly, the amount of PKC gamma in cytosol of hippocampus did not significantly differ between any of the five groups. These results indicate that the three antiepileptic drugs used in this study all disturbed the spatial learning of immature rats. Spatial learning was concomitant with activation of PKC gamma in hippocampal neurons. PB and VPA likely adversely affect learning and memory by interfering with PKC gamma activation, whereas CBZ may act by a different mechanism, possibly in the post-translocation process or by a PKC gamma independent pathway.
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“in animal studies, autistic behaviors have been observed following administration of valproate during prenatal life or during weaning (stereotyped behaviors, social interaction deficit, self-injurious behaviors, enhanced anxiety as well as impaired cognitive, motor, and attention development) (165–167).”
From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [167]
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Cites
Cognitive and Behavioral Effects of Antiepileptic Drugs
Devinsky, O. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb05999.x · Cited by 182
Chronic Sodium Valproate Selectively Decreases Protein Kinase C α and ε In Vitro
Chen, G., Manji, H. K., Hawver, D. B., Wright, C. B., & Potter, W. Z. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062361.x · Cited by 171
Pharmacological evidence for a role of long‐term potentiation in memory
Izquterdo, I. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.14.7958619 · Cited by 100
Paylor, R. E., Baskall-Baldini, L., Yuva‐Paylor, L. A., & Wehner, J. M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1415 · Cited by 71
Watson, D. G., Watterson, J. M., & Lenox, R. H. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37400-2 · Cited by 68
van der Zee, E. A., Luiten, P. G. M., & Disterhoft, J. F. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00017-1 · Cited by 66
Cammarota, M., Paratcha, G., de Stein, M. L., Bernabeu, R., Izquierdo, I., & Medina, J. H. (1997) · Neurochemical Research · doi:10.1023/a:1027324214060 · Cited by 62
Historical review of research on protein kinase C in learning and memory
van der Zee, E. A., & Douma, B. R. K. (1997) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00010-9 · Cited by 61
Jensen, J., & Mørk, A. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(96)00396-3 · Cited by 52
Rogel‐Fuchs, Y., Newman, M. E., Trombka, D., Zahalka, E. A., & Yanai, J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90002-f · Cited by 50
Cited by
Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms
Tordjman, S., Somogyi, E., Coulon, N., Kermarrec, S., Cohen, D., Bronsard, G., Bonnot, O., Weismann-Arcache, C., Botbol, M., Lauth, B., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00053 · Cited by 283
Metadata
- Authors
- Wu, Y., & Wang, L.
- Affiliations
- Peking University First Hospital (CN)
- Corresponding author
- Wu, Ye
- ORCID
- Wu, Ye
- Venue
- Brain and Development
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 24
- Issue
- 2
- Pages
- 82-87
- ISSN
- 0387-7604 (ISSN-L)
- OpenAlex
- W2031054502
- Cited by
- 23
- References
- 16
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- antiepileptic drugs, protein kinase C gamma, spatial learning, hippocampus, phenobarbital, carbamazepine, valproic acid, immature rats, learning and memory, adverse drug reactions
- MeSH terms
- Animals, Anticonvulsants, Carbamazepine, Hippocampus, Immunohistochemistry, Isoenzymes, Learning, Male, Memory Disorders, Phenobarbital, Protein Kinase C, Space Perception, Valproic Acid, Blotting, Western, Rats, Wistar, Rats
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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