Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis
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In young (two months) and aged (18 months) male rats injected s.c. with Freund's adjuvant or adjuvant's vehicle 18 days earlier, 24-h variations in mitogenic responses, lymphocyte subsets and monoamine and amino acid content were examined in submaxillary lymph nodes. Mitogenic responses to concanavalin A (Con A) and lipopolysaccharide (LPS) were higher during the light phase of daily photoperiod. Old rats exhibited a suppressed or impaired mitogenic response to Con A but not to LPS. Acrophases of 24-h rhythm in lymphocyte subset populations in submaxillary lymph nodes were: 18:37-19:44h (B cells), 09:00-10:08h (T and CD4(+) cells) and 12:19-15:58h (CD8(+) cells). Aging augmented B cells and decreased T, CD4(+) and CD8(+) cells. Significant correlations were found between Con A activity and T cells, between lymph node 5HT content and B, T and CD8(+) lymphocytes, and between lymph node 5HT and taurine and GABA content. Aging increased lymph node 5HT content but did not modify NE content. Lymph node concentration of aspartate, glutamate and taurine was higher at night while that of GABA attained peak values at late afternoon. Old rats injected with Freund's adjuvant showed a higher mean value (glutamate) and smaller amplitude (glutamate, taurine) than their respective young controls. The results further document the effects of aging on the chronobiology of the immune system.
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A circadian system independent of prior wakefulness modulates the timing of sleep.
“In addition to this homeostatic component, a second process that is independent from prior wakefulness modulates the timing of sleep, namely, the circadian system.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [64]
Sleep is regulated homeostatically, such that sleep increases in duration and intensity after a prolonged period without sleep.
“Sleep is regulated homeostatically, meaning that sleep increases in duration and intensity after a prolonged period without sleep.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [64]
The homeostatic and circadian components constitute the two factors of the two-process model describing sleep regulation.
“The homeostatic and circadian components constitute the two factors of the so-called two-process model describing the regulation of sleep (64, 65).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [64]
SWS-dependent processes might actively counteract inflammation in the brain.
“SWS-dependent processes might actively counteract inflammation in the brain”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [64]
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References 33 · Cited by 33
- Authors
- Bonacho, M. G., Cardinali, D. P., Castrillón, P., Cutrera, R. A., & Esquifino, A. I.
- Affiliations
- Universidad de Buenos Aires (AR)
- Universidad Complutense de Madrid (ES)
- Corresponding author
- Cardinali, D.P
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 36
- Issue
- 2
- Pages
- 267-282
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2003266406
- Cited by
- 33
- References
- 33
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- Universidad de Buenos Aires
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- aging, 24-hour rhythm, mitogen response, concanavalin A, lipopolysaccharide, lymphocyte subsets, B cells, T cells, CD4 cells, CD8+ T cells, monoamines, serotonin, norepinephrine, amino acids, taurine, glutamate, GABA, aspartic acid, complete Freund's adjuvant-induced arthritis, photoperiod
- MeSH terms
- Aging, Amino Acids, Animals, Arthritis, Experimental, Cell Division, Circadian Rhythm, Concanavalin A, Freund's Adjuvant, Lipopolysaccharides, Lymph Nodes, Male, Mitogens, Submandibular Gland, Lymphocyte Subsets, Rats, Wistar, Neurotransmitter Agents, Rats, In Vitro Techniques
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