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Central Nervous System Infection During Immunosuppression
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Suppression of the immune system by human immunodeficiency virus (HIV) infection or immunosuppressive therapy following transplantation increases susceptibility to CNS infection. Examination of the level and type of immunosuppression, in addition to the clinical and radiologic findings at the time of diagnosis can aid the clinician in determining the most likely etiology of infection. This article discusses how suppression of the host immune status modifies the presentation and diagnosis of selected CNS infections and the recommended treatment for these infections.
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The other herpesviruses (CMV, VZV, and HHV-6) are critical pathogens in certain populations, including immunosuppressed patients, and are best detected in the CNS by molecular methods.
“They are critical pathogens in certain populations, including immunosuppressed patients (34), and are best detected in the CNS by molecular methods (23).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [34]
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Cited by
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Leber, A. L., Everhart, K., Balada-Llasat, J.-M., Cullison, J., Daly, J., Holt, S., Lephart, P., Salimnia, H., Schreckenberger, P. C., DesJarlais, S., et al. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00730-16 · Cited by 609
Tarai, B., & Das, P. (2019) · Neurological Sciences · doi:10.1007/s10072-018-3584-y · Cited by 41
Metadata
- Authors
- Zunt, J. R.
- Affiliations
- University of Washington (US)
- Corresponding author
- Zunt, Joseph R
- ORCID
- Zunt, Joseph R
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 20
- Issue
- 1
- Pages
- 1-22
- ISSN
- 0733-8619 (ISSN-L)
- PMC
- PMC2695971
- OpenAlex
- W2052734639
- Cited by
- 31
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (K23AI001600)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- central nervous system infection, immunosuppression, HIV infection, immunosuppressive therapy, transplantation, opportunistic infections, infection etiology, diagnostic assessment
- MeSH terms
- Biopsy, Brain, Central Nervous System Infections, Humans, Immunosuppression Therapy
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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