OXIDATIVE STRESS AND THE PATHOGENESIS OF HEART FAILURE
Abstract
There is strong evidence for an adverse role of oxidative stress in CHF in both animals and humans. Antioxidant supplement have been very effective in the treatment of animal paradigms; however, the data for the possible benefits of treatment for patients with CHF is either retrospective or inferential. Such information is important and should be the subject of prospective randomized trials.
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The most direct and selective approach to measure specific ROS, notably in the matrix, is to use electron paramagnetic resonance (EPR).
“The most direct and selective approach to measure specific ROS, notably in the matrix, is to use electron paramagnetic resonance (EPR) (16, 129, 151).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [16]
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References 129 · Cited by 53
- Authors
- Ball, A. M. M., & Sole, M. J.
- Affiliations
- University of Toronto (CA)
- Venue
- Cardiology Clinics
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 16
- Issue
- 4
- Pages
- 665-675
- ISSN
- 0733-8651 (ISSN-L)
- OpenAlex
- W1992173543
- Cited by
- 53
- References
- 129
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2021: 1 · 2017: 1 · 2015: 1 · 2013: 3 · 2012: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cardiology Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, heart failure pathogenesis, reactive oxygen species, cardiac dysfunction, myocardial cell death, catecholamines, angiotensin II, cytokines, inflammatory cells, ischemia-reperfusion injury, mitochondrial DNA mutations, protein-energy malnutrition, resting metabolic rate
- MeSH terms
- Animals, Antioxidants, Heart Failure, Humans, Myocardium, Reactive Oxygen Species, Oxidative Stress
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