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Cited by 66Cardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular and exercise physiology

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Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients

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Sasso, Ferdinando Carlo, Carbonara, Ornella, Cozzolino, Domenico, Rambaldi, Pierfrancesco, Mansi, Luigi, Torella, Daniele, Gentile, Sandro, Turco, Salvatore, Torella, Roberto, Salvatore, Teresa·2000·Journal of the American College of Cardiology
DOI 10.1016/s0735-1097(00)00717-8
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Abstract

Objectives The aim of this study was to evaluate: 1) the effects of insulin administration on left ventricular ejection fraction (LVEF) during exercise, and 2) the eventual impairment of the cardiovascular response to insulin in noninsulin dependent diabetes mellitus. Background Insulin influences the cardiovascular system, but its effect on left ventricular function has yet to be established. Methods The effects of normal saline (test A) and insulin-glucose (insulin = 1.7 mU x kg(-1) x min(-1); glucose = 6 mg x kg(-1)min(-1)) (test B) infusions on systolic and diastolic functions at rest and during dynamic exercise were examined by radionuclide ventriculography. Twenty-two noninsulin-dependent diabetic patients and 22 gender, age and body mass index matched healthy subjects were investigated. Results Both groups had normal scintigraphic parameters at rest and during dynamic exercise. Rest- and stress-LVEF as well as rest- and stress-peak filling rate were significantly (p < 0.001) lower in diabetic than in healthy subjects, both in test A and B. Rest-LVEF was significantly higher during test B than it was in test A only in diabetic subjects (p < 0.01). Stress-LVEF was significantly higher (p < 0.05) during test B than it was in test A, in both groups. Insulin-glucose infusion did not modify rest- and stress-peak filling rate in either group. No difference in left ventricular end diastolic volume and in mean blood pressure was found between test A and B at rest and during exercise in either group. A significant linear correlation between LVEF and the index of insulin sensitivity was found in diabetic patients. Conclusions In both normal and diabetic humans, insulin induces a very important rise in LVEF after submaximal work. However, the rise is significantly lower in diabetic than in nondiabetic subjects. The increase in exercise-LVEF on insulin is likely due to an enhancement of ventricular contractility. Insulin resistance could justify the lower angioscintigraphic indexes in diabetic subjects.

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Research works printed but not linked: 35

  1. Lee, 1976, Effects of insulin on cardiac muscle contraction and responsiveness to norepinephrine, Am J Physiol, 230, 1360, 10.1152/ajplegacy.1976.230.5.1360 · DOI
  2. Downing, 1979, Myocardial and coronary vascular responses to insulin in the diabetic lamb, Am J Physiol, 237, H514
  3. Whitlow, 1982, Enhancement of left ventricular function by glucose-insulin-potassium infusion in acute myocardial infarction, Am J Cardiol, 49, 811, 10.1016/0002-9149(82)91963-4 · DOI
  4. Fisher, 1987, The effects of insulin-induced hypoglycemia on cardiovascular function in normal man, Diabetologia, 30, 841, 10.1007/BF00274791 · DOI
  5. Avasthi, 1987, Noninvasive Doppler assessment of human postprandial renal blood flow and cardiac output, Am J Physiol, 252, F1167
  6. Baron, 1993, Insulin differentially regulates systemic and skeletal muscle vascular resistance, Am J Physiol, 265, E61
  7. Baron, 1990, Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity, J Clin Endocrinol Metab, 70, 1525, 10.1210/jcem-70-6-1525 · DOI
  8. Bruce, 1971, Exercise testing of patients with coronary heart disease, Ann Clinical Res, 3, 323
  9. Ziegler, 1992, Assessment of cardiovascular function, Diabet Med, 9, 166, 10.1111/j.1464-5491.1992.tb01754.x · DOI
  10. Raev D. Left ventricular function in young cardiac-asymptomatic type I (insulin-dependent) diabetics. Academic dissertation. Stara Zagora, Stara Zagora Medical University, 1992.
  11. Bacharach, 1997, A real-time system for multi-image gated cardiac studies, J Nucl Med, 18, 79
  12. Borer, 1984, Assessment of ventricular function by radionuclide angiography, Cardiology, 71, 136, 10.1159/000173659 · DOI
  13. Massardo, 1990, Left ventricular volume calculation using a count-based ratio method applied to multigated radionuclide angiography, J Nucl Med, 31, 450
  14. Salvatore, 1992, Decreased insulin clearance as a feature of essential hypertension, J Clin Endocrinol Metab, 74, 144
  15. Airaksinen, 1985, Intravenous insulin has no effect on myocardial contractility or heart rate in healthy subjects, Diabetologia, 28, 649, 10.1007/BF00291969 · DOI
  16. Ferrannini, 1993, Metabolic and hemodynamic effects of insulin on human hearts, Am J Physiol, 264, E308
  17. Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994;267:H187–E202. · DOI
  18. Uusitupa, 1988, Impairment of diastolic function in middle-aged type 1 and type 2 diabetic patients free of cardiovascular disease, Diabetologia, 31, 783, 10.1007/BF00277478 · DOI
  19. Di Bonito, 1996, Diastolic dysfunction in patients with noninsulin-dependent diabetes mellitus of short duration, Diabet Med, 13, 321, 10.1002/(SICI)1096-9136(199604)13:4<321::AID-DIA3>3.0.CO;2-7 · DOI
  20. Celentano, 1995, Early abnormalities of cardiac function in noninsulin-dependent diabetes mellitus and impaired glucose tolerance, Am J Cardiol, 76, 1173, 10.1016/S0002-9149(99)80330-0 · DOI
  21. Lucchesi, 1972, The positive inotropic action of insulin in the canine heart, Eur J Pharmacol, 18, 107, 10.1016/0014-2999(72)90137-9 · DOI
  22. Schaible, 1983, Left ventricular function after chronic insulin treatment in diabetic and normal rats, J Mol Cell Cardiol, 15, 445, 10.1016/0022-2828(83)90264-X · DOI
  23. Regan, 1963, Relationship of insulin and strophanthidin to myocardial metabolism and function, Am J Physiol, 205, 790, 10.1152/ajplegacy.1963.205.4.790 · DOI
  24. Bing, 1953, Metabolic studies on the human heart in vivo, Am J Med, 15, 284, 10.1016/0002-9343(53)90082-5 · DOI
  25. Neely, 1974, Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle, Annu Rev Physiol, 36, 413, 10.1146/annurev.ph.36.030174.002213 · DOI
  26. Heiss, 1977, Myocardial oxygen consumption and substrate uptake in man during physiological and pathological volume load, Basic Res Cardiol, 72, 293, 10.1007/BF01906376 · DOI
  27. Wisneski, 1990, Effects of acute hyperglycemia on myocardial glycolytic activity in humans, J Clin Invest, 85, 1648, 10.1172/JCI114616 · DOI
  28. Lopaschuk, 1992, Developmental changes in energy substrate use by the heart, Cardiovasc Res, 26, 1172, 10.1093/cvr/26.12.1172 · DOI
  29. Camici, 1989, Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans, Am J Physiol, 257, E309
  30. Young, 1975, Inotropic effect of tolbutamide in man, Am Heart J, 89, 189, 10.1016/0002-8703(75)90045-9 · DOI
  31. Schaffer, 1986, Postreceptor myocardial metabolic defect in a rat model of noninsulin-dependent diabetes mellitus, Diabetes, 35, 593, 10.2337/diab.35.5.593 · DOI
  32. Schaffer, 1993, Insulin resistance and mechanical dysfunc-tion in hearts of Wistar rats with streptozotocin-induced noninsulin-dependent diabetes mellitus, Diabetologia, 36, 195, 10.1007/BF00399949 · DOI
  33. Nuutila, 1993, Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes, Am J Physiol, 264, E756
  34. Voipio-Pulkki, 1993, Heart and skeletal muscle glucose disposal in type-2 diabetic patients as determined by positron emission tomography, J Nucl Med, 34, 2064
  35. Young, 1989, Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog, Metab Clin Exp, 38, 1115, 10.1016/0026-0495(89)90049-8 · DOI

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Metadata

Authors
Sasso, F. C., Carbonara, O., Cozzolino, D., Rambaldi, P., Mansi, L., Torella, D., Gentile, S., Turco, S., Torella, R., & Salvatore, T.
Affiliations
  • University of Campania "Luigi Vanvitelli" (IT)
  • University of Naples Federico II (IT)
  • Federico II University Hospital (IT)
Corresponding author
Sasso, Ferdinando Carlo
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2000-07
Volume
36
Issue
1
Pages
219-226
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/s0735-1097(00)00717-8
OpenAlex
W27722483
Cited by
66
References
0
Citations by year
2025: 2 · 2024: 8 · 2023: 6 · 2022: 4 · 2020: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
2.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
insulin, glucose infusion, left ventricular ejection fraction, left ventricular function, physical activity, type 2 diabetes, insulin resistance, insulin sensitivity, ventricular contractility, diastolic filling rate, radionuclide ventriculography
MeSH terms
Adult, Blood Pressure, Diabetes Mellitus, Type 2, Drug Combinations, Electrocardiography, Exercise Test, Female, Glucose, Heart Rate, Heart Ventricles, Humans, Hypoglycemic Agents, Infusions, Intravenous, Insulin, Male, Myocardial Contraction, Prognosis, Rest, Exercise, Radionuclide Ventriculography, Ventricular Function, Left, Ventricular Dysfunction, Left

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