The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Influence of prehospital administration of aspirin and heparin on initial patency of the infarct-related artery in patients with acute st elevation myocardial infarction
Open accessAbstract
Objectives The aim of this study was to investigate the influence of prehospital administration of aspirin and heparin on the initial patency of the infarct-related artery (IRA) in patients with acute myocardial infarction (MI). Background Prehospital diagnosis of acute MI facilitates early pharmacologic intervention on the way to the catheterization laboratory for primary angioplasty. Methods We studied the angiographic data and 30-day clinical outcome of 1,702 patients treated with primary angioplasty; 860 received aspirin and heparin before transportation to our hospital and 842 received aspirin and heparin in our hospital. Results The Thrombolysis In Myocardial Infarction (TIMI) 2 or 3 flow in the IRA was higher in the prehospital treated group (31% vs. 20%, relative risk 0.65, 95% confidence interval 0.55 to 0.78, p < 0.001). Patients with TIMI 2 or 3 flow on the initial angiogram had a higher angioplasty success rate (94% vs. 89%, p < 0.001), a smaller enzymatic infarct size, a higher left ventricular ejection fraction and a lower 30-day mortality (1.6% vs. 3.4%, p = 0.04). Conclusions Prehospital administration of aspirin and heparin results in a higher initial patency of the IRA in patients with acute MI.
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In the citing paper
“For the critical outcome of reinfarction and stroke, and for the important outcome of major hemorrhage, there were no significant differences between the prehospital administration and control groups.”
From Prehospital Administration of Aspirin and Nitroglycerin for Patients With Suspected Acute Coronary Syndrome ― A Systematic Review ― (2022) · cites this paper as [15]
In the citing paper
“Prehospital aspirin administration was associated with significantly lower 30-day and 1-year mortality compared with aspirin administration after arrival at hospital, with odds ratios (OR) of 0.59 (95% confidence interval [CI] 0.35–0.99) and 0.47 (95% CI 0.36–0.62), respectively.”
From Prehospital Administration of Aspirin and Nitroglycerin for Patients With Suspected Acute Coronary Syndrome ― A Systematic Review ― (2022) · cites this paper as [15]
In the citing paper
“For the critical outcome of reinfarction and stroke, and for the important outcome of major hemorrhage, there were no significant differences between the prehospital administration and control groups.”
From Prehospital Administration of Aspirin and Nitroglycerin for Patients With Suspected Acute Coronary Syndrome ― A Systematic Review ― (2022) · cites this paper as [15]
In the citing paper
“No RCTs were identified, and all 3 identified citations were non-RCTs.15–17”
From Prehospital Administration of Aspirin and Nitroglycerin for Patients With Suspected Acute Coronary Syndrome ― A Systematic Review ― (2022) · cites this paper as [15]
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Metadata
- Authors
- Zijlstra, F., Ernst, N., de Boer, M.-J., Nibbering, E., Suryapranata, H., Hoorntje, J. C. A., Dambrink, J.-H. E., van’t Hof, A. W. J., & Verheugt, F. W. A.
- Affiliations
- Isala (NL)
- Corresponding author
- Zijlstra, Felix
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 39
- Issue
- 11
- Pages
- 1733-1737
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2008443325
- Cited by
- 131
- References
- 24
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 2 · 2015: 10 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- acute ST-elevation myocardial infarction, infarct-related artery patency, TIMI flow, primary percutaneous coronary intervention, prehospital thrombolysis, 30-day mortality, left ventricular ejection fraction
- MeSH terms
- Aspirin, Drug Therapy, Combination, Electrocardiography, Emergency Medical Services, Fibrinolytic Agents, Heparin, Humans, Middle Aged, Myocardial Infarction, Angioplasty, Balloon, Coronary, Coronary Angiography
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