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Cited by 101Cardiac pacing and defibrillation studiesCardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Sudden death in implantable cardioverter-defibrillator recipients: clinical context, arrhythmic events and device responses

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Pires, Luis A., Lehmann, Michael H., Steinman, Russell T., Baga, John J., Schuger, Claudio D.·1999·Journal of the American College of Cardiology
DOI 10.1016/s0735-1097(98)00519-1
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Abstract

Objectives We sought to investigate the nature of terminal events and potential contributory clinical and nonclinical (e.g., device-related) factors associated with sudden death (SD) in recipients of an implantable cardioverter-defibrillator (ICD).Background The ICD is very effective in terminating ventricular tachycardia (VT) or ventricular fibrillation (VF), but protection against SD is not absolute. Little is known about the nature and potential causes of SD in patients with ICDs.Methods We analyzed 25 cases of out-of-hospital SD among patients enrolled in the clinical investigation of the Cadence Tiered-Therapy Defibrillator System.Results All patients (24 men and 1 woman, mean age 62+/-10 years) received epicardial lead systems. The majority (92%) had coronary artery disease and a previous myocardial infarction (MI), with a mean left ventricular ejection fraction 0.25+/-0.07. At device implantation, the mean defibrillation threshold was 13+/-5 J. Sudden death occurred 13+/-11 months later. Twenty patients (80%) had received appropriate ICD therapies before death, and 18 (72%) were receiving > or = 1 antiarrhythmic drugs at the time of death. Sudden death was tachyarrhythmia-associated in 16 patients (64%), non-tachyarrhythmia-associated in 7 (28%) and indeterminate in 2 (8%). In the 16 patients with tachyarrhythmia-associated SD, the overall first therapy success rate in tachycardia and fibrillation zones was 60% and 67%, respectively. However, despite protracted therapies (> or = 2 shocks) in 7 (66%) of 12 patients who received fibrillation therapies, the final tachyarrhythmic episode was ultimately terminated by the ICD in 15 (94%) of the 16 patients, whereas 1 patient died after multiple (initially successful) internal and external shocks for intractable VT/VF during exercise. In 10 patients (40%) one or more, primarily clinical, factors potentially contributory to SD were identified: heart failure (n=8), angina (n=2), hypokalemia (n=1), adverse antiarrhythmic drug treatment (n=1) and acute MI (n=1). An additional 10 patients (40%) had experienced an increase in frequency of ICD shocks within 3 months of SD. Appropriate battery voltages and normal circuitry function were found in all devices interrogated and analyzed after death.Conclusions In this select group of patients receiving a third-generation ICD, SD was associated with VT or VF events in nearly two-thirds of patients, and death occurred despite ultimately successful, although often protracted, device therapies. These observations, along with evidence of recent worsening clinical status, suggest acute cardiac mechanical dysfunction as a frequent terminal factor. In recipients with ICDs, SD directly attributable to device failure seems to be rare.

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  1. Davy, 1987, The relationship between successful defibrillation and delivered energy in open-chest dogs, Am J Cardiol, 113, 77

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Metadata

Authors
Pires, L. A., Lehmann, M. H., Steinman, R. T., Baga, J. J., & Schuger, C. D.
Affiliations
Wayne State University (US)
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
1999-01
Volume
33
Issue
1
Pages
24-32
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/s0735-1097(98)00519-1
OpenAlex
W2052429583
Cited by
101
References
37
Citations by year
2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 5
FWCI
4.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Massachusetts General Hospital
  • University of Pennsylvania
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
sudden death, implantable cardioverter-defibrillator, ventricular tachycardia, ventricular fibrillation, antiarrhythmic drugs, heart failure, coronary artery disease, myocardial infarction, hypokalemia, defibrillation threshold, epicardial leads
MeSH terms
Adult, Aged, Cause of Death, Female, Follow-Up Studies, Humans, Male, Middle Aged, Risk Factors, Ventricular Fibrillation, Exercise, Death, Sudden, Cardiac, Defibrillators, Implantable, Tachycardia, Ventricular, Equipment Failure Analysis

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