Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: implications for the diagnosis of pulmonary hypertension
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Objectives The aim of this study was to explore the full range of tricuspid valve regurgitation velocity (TRV) at rest and with exercise in disease free individuals. Additionally we examined the relationship of stroke volume (SV), cardiac output (CO) and TRV to exercise capacity. Background Doppler evaluation of TRV can be used to estimate pulmonary artery systolic pressure (PASP). Most studies have assumed TRV < or = 2.5 m/s as the upper limits of normal. The full range of TRV with exercise has been incompletely defined. Methods Highly conditioned athletes (n = 26) and healthy, active, young male volunteers (n = 14) underwent standardized recumbent bicycle exercise. Exercise parameters included: TRV, SV, CO, systolic (SBP) and diastolic (DBP) systemic blood pressure. Results Tricuspid valve regurgitation, SV, HR and CO were significantly higher in athletes than in nonathletes over all workloads, including rest. Systolic blood pressure and DBP did not show significant differences between the two groups. Conclusions This study defines the upper physiologic limits of TRV at rest and during exercise in normals and provides a noninvasive standard for the diagnosis of pulmonary hypertension.
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Trained athletes during intense exercise demonstrate considerable increases in pulmonary pressures.
“The considerable increases in pulmonary pressures demonstrated in trained athletes during intense exercise 29,30,34 suggest a similar physiological stress, albeit only transient.”
From Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes (2012) · cites this paper as [34]
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- Authors
- Bossone, E., Rubenfire, M., Bach, D. S., Ricciardi, M., & Armstrong, W. F.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Armstrong, William F
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 33
- Issue
- 6
- Pages
- 1662-1666
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1969591792
- Cited by
- 277
- References
- 31
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 15 · 2018: 11 · 2017: 12 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 17
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- tricuspid regurgitation velocity, pulmonary hypertension, exercise testing, athletes, stroke volume, cardiac output, pulmonary artery systolic pressure, Doppler echocardiography, reference values, exercise capacity, systemic blood pressure
- MeSH terms
- Adolescent, Adult, Blood Flow Velocity, Cardiac Output, Exercise Test, Humans, Hypertension, Pulmonary, Male, Reference Values, Rest, Stroke Volume, Tricuspid Valve Insufficiency
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