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Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis
Open accessAbstract
Objectives The study evaluates the clinical course and the development of systolic and diastolic left ventricular function in patients with chronic myocarditis with or without autoantibodies against cardiac myosin. Background Patients with myocarditis often show autoantibodies against cardiac myosin. The clinical and pathophysiologic significance of these antimyosin autoantibodies (AMAAB) is yet unknown. The results from studies comparing the clinical course and the development of left ventricular function in patients with chronic myocarditis with or without AMAAB are not yet available. Methods Thirty-three patients with biopsy proven chronic myocarditis underwent analysis of AMAAB, right and left heart catheterization and left ventriculography at baseline and after six months. Left ventricular volumes and ejection fraction as well as the time constant of left ventricular relaxation "tau" and the constant of myocardial stiffness "b" were determined at baseline and at follow-up. Results In 17 (52%) patients, AMAAB could be detected at baseline. After six months, AMAAB were still found in 13 (76%) initially antibody-positive patients. No initially antibody-negative (n = 16) patient developed AMAAB during follow-up. Clinical symptoms improved slightly in antibody-negative patients and remained stable in antibody-positive patients. Left ventricular ejection fraction developed significantly better in antibody-negative patients (+8.9 +/- 10.1%) compared with antibody-positive patients (-0.1 +/- 9.4%) (p < 0.012). Stroke volume (SV) and stroke volume index (SVI) also improved in antibody-negative patients (SV: +20 +/- 31 ml; SVI: +10 +/- 17 ml) compared with antibody-positive patients (SV: -14 +/- 43 ml; SVI: -8 +/- 22 ml) (SV: p < 0.015; SVI: p < 0.016). Left ventricular end-diastolic and end-systolic volumes and the time constant of left ventricular relaxation "tau" did not change significantly different in antibody-positive and antibody-negative patients. The constant of myocardial stiffness "b" improved significantly in antibody-negative patients (-6.1 +/- 10.8) compared with antibody-positive patients (+7.3 +/- 22.6) (p < 0.040). Analyzing only the persistently antibody-positive patients yielded essentially the same results. Conclusions Antimyosin autoantibodies are associated with worse development of left ventricular systolic function and diastolic stiffness in patients with chronic myocarditis.
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“Some patients with myocarditis showed a correlation between antimyosin antibody titer and the severity of cardiac dysfunction, whereas in others, the titer became undetectable”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [86]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“an elevated level of antimyosin autoantibodies in the serum of both myocarditis patients and murine models, as well as in other cardiovascular disease conditions”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [86]
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Citations
Cites
Myocarditis. A histopathologic definition and classification.
Aretz, H. T., Billingham, M. E., Edwards, W. D., Factor, S. M., Fallon, J. T., Fenoglio, J. J., Olsen, E. G. J., & Schöen, F. J. (1987) · PubMed · Cited by 1,307
Idiopathic Dilated Cardiomyopathy
Dec, G. W., & Fuster, V. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412083312307 · Cited by 957
A new protein of the thick filaments of vertebrate skeletal myofibrils
Offer, G., Moos, C., & Starr, R. (1973) · Journal of Molecular Biology · doi:10.1016/0022-2836(73)90055-7 · Cited by 629
Usefulness and limitations of radiographic methods for determining left ventricular volume
Dodge, H. T., Sandler, H., Baxley, W. A., & Hawley, R. R. (1966) · The American Journal of Cardiology · doi:10.1016/0002-9149(66)90191-3 · Cited by 613
Bowles, N. E., Olsen, E. G. J., Richardson, P. J., & ARCHARD, L. C. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91837-4 · Cited by 601
Myosin isoenzyme redistribution in chronic heart overload
Lompré, A., Schwartz, K., d’Albis, A., Lacombe, G., Thiem, N. V., & Bernard Swynghedauw, A. (1979) · Nature · doi:10.1038/282105a0 · Cited by 523
Cardiac myosin induces myocarditis in genetically predisposed mice.
Neu, N., Rose, N. R., Beisel, K. W., Herskowitz, A., Gurri-Glass, G., & Craig, S. W. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.11.3630 · Cited by 523
Raff, G. L., & Glantz, S. A. (1981) · Circulation Research · doi:10.1161/01.res.48.6.813 · Cited by 444
HAUCK, A. J., Kearney, D. L., & Edwards, W. D. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61286-5 · Cited by 436
Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis
Chow, L. H., Radio, S. J., Sears, T. D., & McManus, B. M. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90465-8 · Cited by 353
Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.
Limas, C. J., Goldenberg, I. F., & Limas, C. (1989) · Circulation Research · doi:10.1161/01.res.64.1.97 · Cited by 332
Caforio, A. L., Grazzini, M., Mann, J. M., Keeling, P. J., Bottazzo, G. F., McKenna, W. J., & Schiaffino, S. (1992) · Circulation · doi:10.1161/01.cir.85.5.1734 · Cited by 315
Kandolf, R., Ameis, D., Kirschner, P., Canu, A., & HOFSCHNEIDER, P. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6272 · Cited by 307
Interobserver variability in the pathologic interpretation of endomyocardial biopsy results.
Shanes, J. G., Ghali, J. K., Billingham, M. E., Ferrans, V. J., Fenoglio, J. J., Edwards, W. D., Tsai, C. C., Saffitz, J. E., Isner, J. M., & Furner, S. (1987) · Circulation · doi:10.1161/01.cir.75.2.401 · Cited by 251
Kühl, U., Noutsias, M., Seeberg, B., & Schultheiß, H. (1996) · Heart · doi:10.1136/hrt.75.3.295 · Cited by 240
Self-citationNeu, N., Beisel, K. W., Traystman, M. D., Rose, N. R., & Craig, S. W. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.8.2488 · Cited by 227
Vogel, W. M., Apstein, C. S., Briggs, L. L., Gaasch, W. H., & Ahn, J. (1982) · Circulation Research · doi:10.1161/01.res.51.4.465 · Cited by 184
The challenge of cardiomyopathy
Abelmann, W. H., & Lorell, B. H. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90293-3 · Cited by 179
Interobserver variability in the pathologic interpretation of endomyocardial biopsy results.
GShanes, J., JGhali, EBillingham, M., JFerrans, V., JFenoglio, J., DEdwards, W., CTsai, C., ESaffitz, J., JIsner, & SFurner (1987) · Circulation · Cited by 150
Diastolic filling dynamics in patients with aortic stenosis.
Murakami, T., Hess, O. M., Gage, J. E., Grimm, J., & Krayenbuehl, H. P. (1986) · Circulation · doi:10.1161/01.cir.73.6.1162 · Cited by 139
Schulze, K. J., Becker, B. F., & Schultheiß, H. (1989) · Circulation Research · doi:10.1161/01.res.64.2.179 · Cited by 137
Heart-specific autoantibodies induced by Coxsackievirus B3: Identification of heart autoantigens
Alvarez, F. L., Neu, N., Rose, N. R., Craig, S. W., & Beisel, K. W. (1987) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(87)90164-4 · Cited by 119
Neu, N., Craig, S. W., Rose, N. R., Álvarez, F., & Beisel, K. W. (1987) · PubMed Central · Cited by 104
Left ventricular passive diastolic properties in chronic mitral regurgitation.
Corin, W. J., Murakami, T., Monrad, E. S., Hess, O. M., & Krayenbuehl, H. P. (1991) · Circulation · doi:10.1161/01.cir.83.3.797 · Cited by 103
Caforio, A. L. P., Goldman, J. H., Haven, A. J., Baig, K. M., Libera, L. D., McKenna, W. J., & Myocarditis Treatment Trial Investigators (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015230 · Cited by 103
Lauer, B., Padberg, K., Schultheiß, H., & Strauer, B. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90513-4 · Cited by 93
Self-citationNew Concepts in Viral Heart Disease
(1988) · Springer eBooks · doi:10.1007/978-3-642-73610-0 · Cited by 91
MYOCARDITIS AND DILATED CARDIOMYOPATHY
KAWAI, C., Matsumori, A., & Fujiwara, H. (1987) · Annual Review of Medicine · doi:10.1146/annurev.me.38.020187.001253 · Cited by 86
Cardiac autoantibodies in dilated cardiomyopathy become undetectable with disease progression.
Caforio, A. L., Goldman, J. H., Baig, M. K., Haven, A. J., Dalla Libera, L., Keeling, P. J., & McKenna, W. J. (1997) · Heart · doi:10.1136/hrt.77.1.62 · Cited by 80
Acute myocarditis: a diagnostic dilemma.
Billingham, M. E. (1987) · Heart · doi:10.1136/hrt.58.1.6 · Cited by 74
Antibodies Against Stress Proteins in Sera of Patients with Dilated Cardiomyopathy
Portig, I., Pankuweit, S., & Maisch, B. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0463 · Cited by 73
Hammond, E. H., Menlove, R. L., & Anderson, J. L. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90180-3 · Cited by 69
Cassling, R. S., Linder, J., Sears, T. D., Waller, B. F., Rogler, W. C., Wilson, J. E., Kugler, J. D., Kay, D. H., Dillon, J. C., Slack, J. D., et al. (1985) · American Heart Journal · doi:10.1016/0002-8703(85)90447-8 · Cited by 69
Cytokines in myocarditis and cardiomyopathies
Matsumori, A. (1996) · Current Opinion in Cardiology · doi:10.1097/00001573-199605000-00011 · Cited by 68
Pankuweit, S., Portig, I., Lottspeich, F., & Maisch, B. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0253 · Cited by 63
Linder, J., Cassling, R. S., Rogler, W. C., Wilson, J. E., Markin, R. S., Sears, T. D., & McManus, B. M. (1985) · PubMed · Cited by 63
Schultheiß, H. (1989) · Springer Seminars in Immunopathology · doi:10.1007/bf00197081 · Cited by 62
Idiopathic dilated cardiomyopathy
Hackel, A. J., Wagner, G. S., & Hackel, D. B. (1994) · Clinical Cardiology · doi:10.1002/clc.4960170510 · Cited by 55
Krogmann, O. N., Rammos, S., Jakob, M., Corin, W. J., Hess, O. M., & Bourgeois, M. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90323-s · Cited by 54
Molecular studies on enteroviral heart disease: patterns of acute and persistent infections
Kandolf, R., Klingel, K., Mertsching, H., Canu, A., Hohenadl, C., Zell, R., Reimann, B.-Y., Heim, A., McManus, B. M., Foulis, A. K., et al. (1991) · European Heart Journal · doi:10.1093/eurheartj/12.suppl_d.49 · Cited by 51
Self-citationNew concepts in viral heart disease
(1989) · Research in Virology · doi:10.1016/s0923-2516(89)80135-9 · Cited by 40
Myocarditis and Cardiomyopathy
James, T. N. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301063080110 · Cited by 36
The Ca-channel as cardiac autoantigen
Kühl, U., Melzner, B., Schafer, B., Schultheiß, H., & Strauer, B. E. (1991) · European Heart Journal · doi:10.1093/eurheartj/12.suppl_d.99 · Cited by 35
Self-citationSteenbergen, C., Kolbeck, P. C., & Wolfe, J. A. (1986) · Journal of applied cardiology · Cited by 29
Pauschinger, M., Kühl, U., Dörner, A., Schieferecke, K., Petschauer, S., Rauch, U., Schwimmbeck, P. L., Kandolf, R., & Schultheiß, H. (1998) · Zeitschrift für Kardiologie · doi:10.1007/s003920050199 · Cited by 28
Self-citationFunctional analysis of autoantibodies against ADP/ATP carrier from dilated cardiomyopathy
Liao, Y. (1996) · International Journal of Cardiology · doi:10.1016/0167-5273(96)02594-6 · Cited by 25
Limas, C. J., Limas, C., Goldenberg, I. F., & Blair, R. (1995) · American Heart Journal · doi:10.1016/0002-8703(95)90395-x · Cited by 23
Schwimmbeck, P. L., Bland, N. K., Schultheiß, H., & Strauer, B. E. (1991) · European Heart Journal · doi:10.1093/eurheartj/12.suppl_d.76 · Cited by 22
Self-citationKühl, U., Daun, B., Seeberg, B., Schultheiß, H., & Strauer, B. E. (1992) · PubMed · Cited by 20
Self-citationThe problem of viral heart disease. How often do we miss it?
Olsen, E. G. J. (1985) · Postgraduate Medical Journal · doi:10.1136/pgmj.61.716.479 · Cited by 20
Morimoto, S.-I., Hiramitsu, S., Yamada, K., Uemura, A., Kubo, N., Kimura, K., Mizuno, Y., Nishikawa, T., Hasumi, M., & Sekiguchi, M. (1992) · PubMed · Cited by 17
Evaluation of Immunohistological Data for the Diagnosis of Myocarditis
Kühl, U., Toussaint, M., Ulrich, G., Wagner, D. G., Wolff, P. G., & Schultheiß, H.-P. (1988) · Springer eBooks · doi:10.1007/978-3-642-73610-0_31 · Cited by 17
Self-citationMyocarditis and dilated cardiomyopathy: different stages of the same disease?
Fallon, J. T. (1988) · PubMed · Cited by 13
Maisch, B., Herzum, M., Izumi, T., & Nunoda, S. (1988) · Springer eBooks · doi:10.1007/978-3-642-73610-0_25 · Cited by 8
Lauer, B., Kühl, U., Souvatzoglu, M., Vosberg, H., & Schultheiß, H. (1998) · Zeitschrift für Kardiologie · doi:10.1007/s003920050228 · Cited by 6
Self-citation
Research works printed but not linked: 4
- Aretz, 1987, Myocarditis, Am J Cardiovasc Pathol, 1, 3
- Kühl, 1992, Dilative Kardiomyopathie-eine chronische Myokarditis? Immunhistologische Charakterisierung lymphozytärer Zellen, Herz, 17, 97
- Morimoto, 1992, Clinical and pathologic features of chronic myocarditis, Am J Cardiovasc Pathol, 4, 181
- Neu, 1987, Coxsackie virus induced myocarditis in mice, Clin Exp Immunol, 69, 566
Cited by
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Schultheiss, H.-P., Fairweather, D., Caforio, A. L. P., Escher, F., Hershberger, R. E., Lipshultz, S. E., Liu, P. P., Matsumori, A., Mazzanti, A., McMurray, J., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0084-1 · Cited by 720
Caforio, A. L. P., Calabrese, F., Angelini, A., Tona, F., Vinci, A., Bottaro, S., Ramondo, A. B., Carturan, E., Iliceto, S., Thiene, G., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm076 · Cited by 487
The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy
Heymans, S., Eriksson, U., Lehtonen, J., & Cooper, L. T. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.937 · Cited by 359
Caforio, A. L. P., Mahon, N., Tona, F., & McKenna, W. J. (2002) · European Journal of Heart Failure · doi:10.1016/s1388-9842(02)00010-7 · Cited by 271
Metadata
- Authors
- Lauer, B., Schannwell, M., Kühl, U., Strauer, B.-E., & Schultheiss, H.-P.
- Affiliations
- Leipzig University (DE)
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Lauer, Bernward
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 35
- Issue
- 1
- Pages
- 11-18
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2078336460
- Cited by
- 197
- References
- 55
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 11 · 2012: 6
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- chronic myocarditis, left ventricular function, systolic function, diastolic function, left ventricular ejection fraction, myocardial stiffness, left ventricular relaxation, stroke volume, autoantibody persistence, left ventriculography, cardiac catheterization, left ventricular volume
- MeSH terms
- Adult, Aged, Autoantibodies, Autoimmune Diseases, Biopsy, Chronic Disease, Diastole, Endocardium, Female, Humans, Male, Middle Aged, Myocardial Contraction, Myocarditis, Myosins, Stroke Volume, Systole, Ventricular Function, Left, Ventricular Dysfunction, Left
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