Cited by 178Cardiovascular Health and Disease PreventionCardiovascular Function and Risk FactorsElasticity and Material Modeling

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Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk

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Anderson, Todd J.·2006·Canadian Journal of Cardiology

DOI 10.1016/s0828-282x(06)70990-4PMC PMC2780833

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Abstract

The understanding of the pathophysiology of atherosclerosis has advanced greatly in the past decade. Cardiovascular risk factors increase the likelihood of an adverse event by having a detrimental effect on the blood vessel wall. Abnormal interactions among cholesterol, inflammatory mediators, platelets and the vascular wall lead to atherogenesis and cardiac events. In an effort to better understand this process, develop surrogate end points for clinical trials and, ultimately, better risk stratify individuals, a variety of measures of arterial function have been studied. These include measures of endothelial health and arterial compliance. The current paper reviews the various techniques available for the study of vascular health. While not yet routinely used for clinical care, these measurements provide important insights into the pathophysiology and treatment of atherosclerosis.

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Authors: Anderson, T. J.
Affiliations: University of Alberta (CA)
Corresponding author: Anderson, Todd J.
ORCID: Anderson, Todd J.
Venue: Canadian Journal of Cardiology
Publisher: Elsevier BV
Published: 2006-02
Volume: 22
Pages: 72B-80B
ISSN: 0828-282X (ISSN-L)
DOI: 10.1016/s0828-282x(06)70990-4
PMC: PMC2780833
OpenAlex: W1994138576
Cited by: 178
References: 127
Citations by year: 2026: 1 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 22 · 2016: 15 · 2015: 14 · 2014: 11 · 2013: 4 · 2012: 6
FWCI: 0.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Canadian Journal of Cardiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Keywords: arterial stiffness, endothelial dysfunction, surrogate markers, vascular risk, atherosclerosis, arterial compliance, cardiovascular risk stratification, surrogate endpoints, atherogenesis
MeSH terms: Arteries, Blood Pressure, Cardiovascular Diseases, Compliance, Elasticity, Endothelium, Vascular, Humans, Prognosis, Risk Factors, Biomarkers, Atherosclerosis

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Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk

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