Cannabis Reduces Opioid Dose in the Treatment of Chronic Non-Cancer Pain
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One case series (n = 3) provided very low-quality evidence of a reduction in opioid requirements with cannabinoid co-administration.
“One case series (n = 3) provided very low-quality evidence of a reduction in opioid requirements with cannabinoid co-administration.”
From Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis (2017) · cites this paper as Lynch et al, 2003
The only clinical study that provided direct evidence of an opioid-sparing effect was rated as providing very low-quality evidence.
“The only study that provided direct evidence of an opioid-sparing effect was rated as providing very low-quality evidence (Lynch et al, 2003).”
From Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis (2017) · cites this paper as Lynch et al, 2003
In Lynch 2003, mean baseline morphine dose was 195 mg (SD 147 mg) compared with 35 mg (SD 31 mg) after commencing smoked cannabis; there was opioid dose reduction or cessation in each case; improved pain control was described.
“Mean baseline morphine dose of 195 mg (SD 147 mg) compared with 35 mg (SD 31 mg) after commencing smoked cannabis.Opioid dose reduction or cessation in each case Improved pain control described, with patients either reducing or ceasing morphine dose”
From Opioid-Sparing Effect of Cannabinoids: A Systematic Review and Meta-Analysis (2017) · cites this paper as Lynch 2003
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References 7 · Cited by 56
Research works printed but not linked: 2
- Walker MJ, Strangman NM, Huang SM. Canna- binoids and pain. Pain Res Manage 2001;6:74-79.
- Tsou K, Lowitz KA, Hohmann AG, et al. Suppres- sion of noxious stimulus-evoked expression of Foslike immunoreactivity in rat spinal cord by a selective cannabinoid agonist. Neuroscience 1995; 70:791-798.
- Authors
- Lynch, M. E., & Clark, A. J.
- Affiliations
- Dalhousie University (CA)
- ORCID
- Lynch, Mary E
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 25
- Issue
- 6
- Pages
- 496-498
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2083600976
- Cited by
- 56
- References
- 7
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- cannabis, cannabinoids, chronic non-cancer pain, opioid dose reduction, opioid-sparing effect, tetrahydrocannabinol, endocannabinoid system, pain modulation, opioid analgesia, familial Mediterranean fever, neuropathic pain, inflammatory pain
- MeSH terms
- Adult, Analgesics, Opioid, Cannabis, Chronic Disease, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Humans, Male, Phytotherapy, Middle Aged, Pain, Plant Preparations
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