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TOXICITY OF CHEMOTHERAPY
Abstract
Because anticancer drugs are cytotoxic for normal as well as neoplastic cells, the range of unwanted effects that accompanies their use is broad. Many of the side effects are potentially life-threatening or seriously debilitating. Many are similar to, and readily confused with, direct or indirect (paraneoplastic) consequences of the cancer itself. Recognition of drug side effects is vital for optimal patient care, because early withdrawal of the offending agent and institution of appropriate treatment have the potential to significantly reduce the overall morbidity and mortality associated with the diagnosis of cancer.
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“Chemotherapy, in particular, is known for its systemic toxicity. Although chemotherapeutic agents are designed to target rapidly dividing cells, many normal cells such as those in the gastrointestinal tract, bone marrow, and hair follicles also divide rapidly and become unintended targets [16].”
From Advances in green-synthesized magnetic nanoparticles for targeted cancer therapy: mechanisms, applications, and future perspectives (2026) · cites this paper as [16]
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Thrombopoietin: the primary regulator of platelet production [see comments]
Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642
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El-khawaga, A. M., Youssef, O. I., El-dydamoni, O. A., Ragab, W. M., & Mohammed, R. A. E. (2026) · European Journal of Medical Research · doi:10.1186/s40001-025-03804-9 · Cited by 14
Metadata
- Authors
- Lowenthal, R. M., & Eaton, K.
- Venue
- Hematology/Oncology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 10
- Issue
- 4
- Pages
- 967-990
- ISSN
- 0889-8588
- Cited by
- 104
- References
- 1
- Language
- en
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