The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Selective Sensitization to the Psychosis-Inducing Effects of Cocaine: A Possible Marker for Addiction Relapse Vulnerability?
Abstract
Patients in inpatient rehabilitation for uncomplicated cocaine dependence were asked whether, compared with the time of their first regular use, they could now identify changes in the effects of similar doses of cocaine. We asked about a spectrum of cocaine effects "then" and "now" and whether the same amount of drug caused effects to occur to about the same degree, less intensely (tolerance), or more intensely (sensitization). Nearly half our sample developed predominantly paranoid psychoses in the context of cocaine use. Sensitization was consistently linked only to psychosis-related cocaine effects. It has been proposed that mesolimbic dopaminergic sensitization might contribute to addiction severity. A preliminary followup of patients who were sensitized or nonsensitized to psychosis development suggests that rehospitalization for treatment of addiction may be more frequent in the sensitized group.
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“However, repeated drug intake does not appear to produce a sensitization of ‘liking’ (Bartlett, Hallin, Chapman, & Angrist, 1997).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Bartlett, Hallin, Chapman, & Angrist, 1997
In the citing paper
“Yet, sensitization does not increase ‘liking’ reactions that reflect the hedonic impact of the reward when it actually arrives (Bartlett et al., 1997).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Bartlett et al., 1997
In the citing paper
“In humans, several reports have provided evidence of sensitization in psychostimulant drug users leading to enhanced drug-seeking, despite showing tolerance to the drug’s euphoric effects (Bartlett et al., 1997; Reed et al., 2009; Small et al., 2009).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Bartlett et al., 1997
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Metadata
- Authors
- Bartlett, E.
- Affiliations
- Veterans Health Administration (US)
- Corresponding author
- Bartlett, E
- Venue
- Neuropsychopharmacology
- Published
- 1997-01
- Volume
- 16
- Issue
- 1
- Pages
- 77-82
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2042464546
- Cited by
- 160
- References
- 7
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 45 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 6
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cocaine, drug sensitization, tolerance (pharmacology and immunology), paranoia, psychosis, cocaine dependence, addiction relapse, hospital readmission, mesolimbic dopamine system, inpatient rehabilitation, subjective drug effects
- MeSH terms
- Adult, Cocaine, Female, Humans, Male, Opioid-Related Disorders, Narcotics, Paranoid Disorders, Psychoses, Substance-Induced, Recurrence, Biomarkers, Crack Cocaine
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