The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Compliance and Antihypertensive Efficacy of Amlodipine Compared With Nifedipine Slow-Release
Abstract
Poor compliance is a principal cause of treatment failure in hypertensive patients. Once-daily dosing improves compliance, but 24-h antihypertensive activity should be provided. The compliance, efficacy, and safety of amlodipine and nifedipine slow-release (SR) were compared in patients with mild-to-moderate essential hypertension recruited among 24 centers in France. After a 2-week washout period, 103 patients were randomized to 12 weeks of 5 to 10 amlodipine mg once daily (n = 55) or 20 mg nifedipine SR twice daily (n = 48). Compliance was calculated by electronic drug monitoring. Efficacy was measured by ambulatory and casual BP recordings. Patients receiving amlodipine demonstrated better compliance than patients receiving nifedipine SR with respect to compliance index (the total number of doses taken divided by the total number of doses prescribed, expressed as a percentage; 98.3% v 87%; P < .0001), days on which the correct number of doses were taken (92.5% v 74.8%; P < .0001), and prescribed doses taken on schedule (88.7% v 71.6%; P < .0001). Absolute and relative therapeutic coverage were higher in patients receiving amlodipine than nifedipine SR (P < .0001). Mean SBP and DBP decreased equally in both groups, although amlodipine offered better BP control compared with nifedipine SR at specific times of day. Fewer patients had high nocturnal SBP with amlodipine (39.3%) than nifedipine SR (71.4%; P = .042). Adverse events and treatment withdrawals occurred less frequently in amlodipine-treated patients than in nifedipine SR-treated patients. Amlodipine (5 to 10 mg) once daily provides improved compliance, better 24-h BP control, and fewer adverse events than 20 mg nifedipine SR twice daily in patients with mild-to-moderate hypertension.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Blood pressure, stroke, and coronary heart disease
Collins, R., Peto, R., MacMahon, S., Godwin, J., Qizilbash, N., Collins, R., MacMahon, S., Hebert, P., Eberlein, K. A., Taylor, J. O., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)90944-z · Cited by 4,491
Circadian variation of blood-pressure
Millar-Craig, M., Bishop, C., & Raftery, E. B. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92998-7 · Cited by 1,293
Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension.
Verdecchia, P., Schillaci, G., Guerrieri, M., Gatteschi, C., Benemio, G., Boldrini, F., & Porcellati, C. (1990) · Circulation · doi:10.1161/01.cir.81.2.528 · Cited by 1,224
O'Brien, E., Sheridan, J., & O'Malley, K. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92867-x · Cited by 1,021
Pickering, T. G. (1982) · JAMA · doi:10.1001/jama.247.7.992 · Cited by 526
Blackwell, B. (1973) · New England Journal of Medicine · doi:10.1056/nejm197308022890506 · Cited by 506
Shimada, K., Kawamoto, A., Matsubayashi, K., Nishinaga, M., Kimura, S., & Ozawa, T. (1992) · PubMed · Cited by 454
Stamler, R. (1987) · JAMA · doi:10.1001/jama.257.11.1484 · Cited by 273
Faulkner, J. K., McGibney, D., Chasseaud, L. F., Perry, J., & Taylor, I. W. (1986) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1986.tb02874.x · Cited by 230
Cited by
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388
Schroeder, K., Fahey, T., & Ebrahim, S. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.7.722 · Cited by 416
Lehane, E., & McCarthy, G. (2007) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2006.07.010 · Cited by 303
Medication adherence and persistence: A comprehensive review
Krueger, K. P., Berger, B. A., & Felkey, B. (2005) · Advances in Therapy · doi:10.1007/bf02850081 · Cited by 317
for the ABC project team, Demonceau, J., Ruppar, T., Kristanto, P., Hughes, D. A., Fargher, E., Kardas, P., De Geest, S., Dobbels, F., Lewek, P., et al. (2013) · Drugs · doi:10.1007/s40265-013-0041-3 · Cited by 307
Metadata
- Authors
- Mounier-Vehier, C.
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-04
- Volume
- 11
- Issue
- 4
- Pages
- 478-486
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W1964491414
- Cited by
- 37
- References
- 24
- Citations by year
- 2026: 3 · 2023: 1 · 2021: 1 · 2019: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- amlodipine, essential hypertension, medication adherence, antihypertensive efficacy, once-daily dosing, 24-hour blood pressure control, nocturnal blood pressure, calcium channel blockers, adverse events
- MeSH terms
- Adolescent, Adult, Aged, Antihypertensive Agents, Blood Pressure, Calcium Channel Blockers, Delayed-Action Preparations, Female, Humans, Hypertension, Male, Middle Aged, Nifedipine, Patient Compliance, Treatment Outcome, Amlodipine, Blood Pressure Monitoring, Ambulatory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Compliance and Antihypertensive Efficacy of Amlodipine Compared With Nifedipine Slow-Release. https://app.cochat.ai/papers/10.1016/s0895-7061(97)00485-8
- The paper
- Mounier-Vehier, C. (1998). Compliance and Antihypertensive Efficacy of Amlodipine Compared With Nifedipine Slow-Release. American Journal of Hypertension. https://doi.org/10.1016/s0895-7061(97)00485-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
