The EGF and FGF Receptors Mediate Neuroglian Function to Control Growth Cone Decisions during Sensory Axon Guidance in Drosophila
Open accessAbstract
Cell adhesion molecules (CAMs) implement the process of axon guidance by promoting specific selection and attachment to substrates. We show that, in Drosophila, loss-of-function conditions of either the Neuroglian CAM, the FGF receptor coded by the gene heartless, or the EGF receptor coded by DER display a similar phenotype of abnormal substrate selection and axon guidance by peripheral sensory neurons. Moreover, neuroglian loss-of-function phenotype can be suppressed by the expression of gain-of-function conditions of heartless or DER. The results are consistent with a scenario where the activity of these receptor tyrosine kinases is controlled by Neuroglian at choice points where sensory axons select between alternative substrates for extension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ksr and Neuroglian (Nrg) promote ERK signaling.
“both of which promote ERK signaling (133–136)”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [135]
The passage labeled Abstract (page unavailable) describes Neuroglian acting through the FGF and EGF receptors during axon guidance, and separately says that L1 can signal through the MAP kinase pathway. It does not establish that Neuroglian promotes ERK signaling. A search for ksr and ERK signaling found no passage addressing ksr’s role either. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 44 · Cited by 79
- Authors
- García-Alonso, L., Romani, S., & Jiménez, F.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 28
- Issue
- 3
- Pages
- 741-752
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1966987832
- Cited by
- 79
- References
- 44
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- European Commission
- Ministerio de Economía y Competitividad
- Generalitat Valenciana
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Neuroglian, EGF receptor, fibroblast growth factor receptor, DER, receptor tyrosine kinase, axon guidance, sensory axons, adhesion molecules, Drosophila, peripheral sensory neurons
- MeSH terms
- Animals, Axons, Drosophila, Mutation, Neuroglia, Neurons, Afferent, Phenotype, Protein-Tyrosine Kinases, Pupa, Receptors, Fibroblast Growth Factor, Growth Cones, Drosophila Proteins, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
