Postsynaptic Levels of [Ca2+]i Needed to Trigger LTD and LTP
Open accessAbstract
Long-term potentiation (LTP) and long-term depression (LTD) in CA1 pyramidal neurons are both triggered by a postsynaptic rise in intracellular Ca2+ concentration ([Ca2+]i). We used photolysis of postsynaptic caged Ca2+ compounds to search for differential thresholds for activation of these processes. Long-lasting potentiation (LLP) resembling LTP, and long-lasting depression (LLD) resembling LTD, were evoked by [Ca2+]i elevations of comparable magnitude and duration in different cells. No distinctions in threshold for these processes were detectable. LLP was occluded by tetanically induced LTP and blocked by calmodulin inhibition, and LLD was occluded by electrically induced LTD and blocked by phosphatase inhibition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prior LTP occluded the photo-induced potentiation.
“prior LTP occluded the photo-induced potentiation (182).”
From Synaptic memory and CaMKII (2023) · cites this paper as [182]
The citation lists haven’t been fetched yet
References 59 · Cited by 198
- Authors
- Neveu, D., & Zucker, R. S.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Zucker, Robert S.
- ORCID
- Zucker, Robert S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 619-629
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2168553595
- Cited by
- 198
- References
- 59
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 3 · 2012: 4
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-15114, R01NS015114)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- long-term potentiation, long-term depression, postsynaptic calcium, intracellular calcium concentration, CA1 pyramidal neurons, calmodulin, phosphatase inhibition, tetanic stimulation
- MeSH terms
- Age Factors, Animals, Calcium, Cell Count, Electric Stimulation, Hippocampus, Photolysis, Time Factors, Rats, Sprague-Dawley, Calcium Compounds, Long-Term Potentiation, Pyramidal Cells, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
