The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Transgenic Rat Model of Charcot-Marie-Tooth Disease
Open accessAbstract
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans and has been associated with a partial duplication of chromosome 17 (CMT type 1A). We have generated a transgenic rat model of this disease and provide experimental evidence that CMT1A is caused by increased expression of the gene for peripheral myelin protein-22 (PMP22, gas-3). PMP22-transgenic rats develop gait abnormalities caused by a peripheral hypomyelination, Schwann cell hypertrophy (onion bulb formation), and muscle weakness. Reduced nerve conduction velocities closely resemble recordings in human patients with CMT1A. When bred to homozygosity, transgenic animals completely fail to elaborate myelin. We anticipate that the CMT rat model will facilitate the identification of a cellular disease mechanism and serve in the evaluation of potential treatment strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Peripheral Myelin Protein‐22 is Expressed in Rat and Mouse Brain and Spinal Cord Motoneurons
Parmantier, E., Cabon, F., Braun, C., D'Urso, D., Müller, H. W., & Zalc, B. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01095.x · Cited by 96
Cited by
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036
Self-citationDe Sandre-Giovannoli, A., Chaouch, M., Kozlov, S., Vallat, J.-M., Tazir, M., Kassouri, N., Szepetowski, P., Hammadouche, T., Vandenberghe, A., Stewart, C. L., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339274 · Cited by 565
Sereda, M. W., Meyer zu Hörste, G., Suter, U., Uzma, N., & Nave, K.-A. (2003) · Nature Medicine · doi:10.1038/nm957 · Cited by 310
Self-citationThe PMP22 Gene and Its Related Diseases
Li, J., Parker, B., Martyn, C., Natarajan, C., & Guo, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-012-8370-x · Cited by 280
The Axon-Myelin Unit in Development and Degenerative Disease
Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246
Self-citation
Metadata
- Authors
- Sereda, M., Griffiths, I., Pühlhofer, A., Stewart, H., Rossner, M. J., Zimmermann, F., Magyar, J. P., Schneider, A., Hund, E., Meinck, H.-M., Suter, U., & Nave, K.-A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 16
- Issue
- 5
- Pages
- 1049-1060
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2170854435
- Cited by
- 381
- References
- 1
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Transgenic Rat Model of Charcot-Marie-Tooth Disease. https://app.cochat.ai/papers/10.1016/s0896-6273(00)80128-2
- The paper
- Sereda, M., Griffiths, I., Pühlhofer, A., Stewart, H., Rossner, M. J., Zimmermann, F., Magyar, J. P., Schneider, A., Hund, E., Meinck, H.-M., Suter, U., & Nave, K.-A. (1996). A Transgenic Rat Model of Charcot-Marie-Tooth Disease. Neuron. https://doi.org/10.1016/s0896-6273(00)80128-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
